Other

Georgia Research Foundation, Inc.

David R Whitmire

J Phillip Bowen

M Scott Furness

Jack Arbiser

The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity as angiogenesis inhibitors, which find use as antitumor/anticancer agents as well as to treat a number of conditions or disease states in which angiogenesis is a factor.

Solenopsin A, B and analogs and as novel angiogenesis inhibitors

Solenopsin derivatives and analogues as fire ant suppressants

An oral controlled release dosage form for cyanamide whereby a portion of a cyanamide dose administered to a patient remains transiently partitioned within encapsulating material, thereby retarding metabolism of the total administered cyanamide dose, is described. No investigator has reported the use of dosage forms enabling controlled release of cyanamide. The preparation, when administered to ethanol metabolizing individuals, can elevate blood acetaldehyde to such levels, and for such periods of time, that the individuals will be deterred from future alcohol consumption. The controlled release of cyanamide provides an optimal time-profile of alcohol deterrence specific for individual patients. The formulation avoids the side-effects associated with the relatively high concentrations of cyanamide and cyanamide-metabolites, and the attendant untoward toxic effects, caused by a typical bolus cyanamide dose, thereby attenuating the intensity of the sickness caused by acetaldehyde, and increasing patient compliance with cyanamide therapy.

Oral formulations for controlled release of alcohol deterrents

In accordance with the present invention, methods and systems consistent with the present invention facilitate the transmission of secure messages across an insecure network. The sender requests a recipient's security software object by, for example, clicking on a button or icon on the recipient's web page. A security software object with encapsulated security information and routing information is transmitted to the sender. The sender composes a message using the security software object. When sender indicates completion, the security software object secures the message according to the security procedure of the object and transmits the secured message to the recipient.

Methods and systems for facilitating transmission of secure messages

A method and formulations have been developed to accelerate ethanol elimination from the body, which combine enzymes that oxidize alcohol to acetate, enzymes which regenerate NADH to NAD, substrates which are rate limiting for the requisite enzymes, buffering agents which protect the enzymes against pH variations (e.g. low gastric pH), gastric acid sequestrants which block synthesis of gastric acid, protease inhibiting agents and other agents which protect the enzymes against proteolysis, carbohydrates which protect labile enzymes against bile salt inactivation, and a source of oxygen for efficient catalysis by some of the enzymes, with a packaging for delivery of a functional enzyme system to an appropriate in vivo site for ethanol conversion to acetate. The oxygen source can be mechanical means, such as a tube or catheter which directs oxygen from a high pressure source into the upper gastrointestinal tract for the most rapid removal of ethanol from the blood as in the case where a patient has overdosed and is unconscious, a physical carrier of oxygen, for example, oxygen microencapsulated in an appropriate polymeric matrix, or an oxygen generating formulation such as catalase (one to ten million units) with hydrogen peroxide (0.1-200 grams), which is stable to passage through the stomach and releases oxygen in the gastrointestinal tract. The formulation is preferably administered orally, although it can also be packaged for administration in any surface through which rapid transport of ethanol from blood to the enzymes can occur. A preferred surface for rapid ethanol transport is mucosal membrane such as is found in the intestine or mouth.

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Watkinsville, GA, United States of America

David R Whitmire