The Upjohn Co.

Other

David R White

Richard Charles Thomas

Clarence J Maring

James B Heather

William G Salmond

Jerry A Walker

Gary Edward Zurenko

Edward L Fritzen, Jr

James J Vavra

Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl

Treating chlamydia infections using spectinomycin analogs

Disclosed are 6'-thiomethylsubstituted spectinomycins (XII) which are useful in the same way as other spectinomycin pharmaceutical agents. 6'-Thiomethylsubstituted (XIV) and protected spectinomycin (XIII) intermediates useful in the production of 6'-thiomethylsubstituted spectinomycins (XII) and 6'-alkenylspectinomycins (IX) are also disclosed.

6'-thiomethylsubstituted spectinomycins

The present invention relates to novel methods of preparing a wide variety of spectinomycin analogs and biologically acceptable salts thereof. Further, the invention relates both to novel intermediates and novel products therein. The novel products are spectinomycin analogs which can be used for the same biological purposes as spectinomycin. The processes of the invention provide for novel intermediates that are versatile and highly reactive exocyclic enones.

Processes for the preparation of spectinomycin analogs, novel products

The present invention relates to novel compounds and processes. In particular, the invention relates to novel analogs of the aminocyclitol antibiotic spectinomycin. More particularly, it relates to novel processes for synthesizing analogs of spectinomycin; both known analogs and the novel analogs of the present invention. Additionally, the invention includes novel intermediates. The novel analogs of spectinomycin disclosed herein are useful as antimicrobial agents.

Analogs of the antibiotic spectinomycin

The invention concerns a method for the synthesis of 6'-ethyl spectinomycin and analogs thereof, including intermediates utilized in the method. The method comprises converting an enamine by a Grignard addition to various novel dienones not hitherto known. The dienones are then hydrogenated and deblocked to obtain 6'-ethyl spectinomycin and analogs thereof. The 6'-ethyl spectinomycin and analogs thereof prepared by the invention exhibit especially good antibacterial activity.

Synthesis of spectinomycin analogs by an improved Grignard process

Process for preparing 6'-alkylspectinomycin and analogs thereof. Also provided are novel intermediates utilized in the process.

6'-Alkylspectinomycins

Processes for the preparation of spectinomycin analogs, products and

A method for the preparation of 6'-methylspectinomycin and analogs thereof. Additionally provides novel intermediates utilized in said method.

Process and intermediates for preparing 6'-methylspectinomycin and

Anomers and asteric mixtures of novel analogs of spectinomycin. Additionally provides novel intermediates and process for preparing spectinomycin and analogs thereof.

Process for preparing spectinomycin analogs

An electrically operated locking system for securing two heavy gate members together, and at least one of the gate members is moveable. The system includes a locking mechanism mounted on one gate member and a latch bolt fixed to the other gate member. The locking mechanism includes latch members that receive the latch bolt therebetween and a lock pin connected to an electrically actuated linkage that secures the latch bolt in the latch members. The locking system includes a mechanical lock-out feature, and it has the capability of being operated from a remote site.

Lock mechanism

Enamines of 6'-methylspectinomycin and process for preparing the same

Process for preparing 6'-methylspectinomycin and analogs thereof

Anomers and asteric mixtures of novel analogs of spectinomycin. Additionally provides novel intermediates and process for preparing spectinomycin analogs.

Growing community of inventors

Kalamazoo, MI, United States of America

David R White