Abbott Laboratories Corporation

David R Mees

Peter J Tarcha

Mark R Pope

Terry A Pry

Mary K Joseph

Daniel D Subotich

C Brent Putman

A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.

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St. Louis, MO, United States of America

David R Mees