Other

Biosource Technologies, Inc.

Adapx, Inc.

Large Scale Biology Corporation

David R McGee

Robert L Erwin

David L Berliner

Paulo Barthelmess

Philipp Heinz Schmid

Michael B Robin

Philip R Cohen

Scott Lind

Phil Cohen

Monto H Kumagai

Guy R Della-Cioppa

Erik M Erikson

Robert Paratore

Edward C Kaiser

Ira Smith

R Matthews Wesson

Alex A Arthur

A digital paper-enabled product includes digital paper with a digital pattern that spatially cooperates with one or more features or boundaries printed on the pattern. More specifically, a system cooperating with the product may include spatial information systems that manage the features or boundaries and communicates with a writing instrument that was used to effect changes to the digital paper-enabled product. In one embodiment, the digital paper-enabled product may take the form of a sheet of digital paper bearing a digital pattern and where action icons (e.g. user intended actions) and/or features (e.g. such as map features) or a spatial reference frame are printed onto the digital pattern and where at least one action palette is printed onto the digital pattern, correlated therewith, and usable to effect changes to the product. Other embodiments include a method of making the digital-enabled product, a method of processing information obtained from the digital paper-enabled product, and a method of using the digital paper-enabled product.

Digital paper-enabled products and methods relating to same

A digital palette and a digital pen device are used to create or manipulate a digital document to provide complex information using features, such as graphical features selected from stencils, shapes, and connectors and possibly to apply one or more attributes to the digital document. The digital palette may have a custom layout. The features on the digital palette may be selected from a variety of sources, such as digital stencil libraries. The digital palette and digital document may be arranged on the same or different sheets of digital paper overlying one or more digital patterns. Information communicated from the digital palette to the digital document may be uploaded, processed, reviewed, changed and stored in a computer. Lastly, the digital document may be finalized and printed to incorporate all changes previously made using the digital palette, the digital pen device and the computer.

Systems and methods for using a digital palette to produce a digital document

A decision assistance device provides a user the ability to access and obtain actionable intelligence or other information to make tactical and strategic decisions. The decision assistance device allows the user to obtain information for future, near-future, and/or real time scenarios. The device advantageously provides the information to the user in a manner that minimizes an amount of attention and interaction required by the user while still permitting the user to rapidly manipulate the device while moving down a desired decision path. The decision assistance device may take a physical or virtual form.

Decision assistance device and methods of using same

The system and method as described herein can be advantageously used in a plurality of scenarios, two of which include field markup and data collection and collaborative review. The system and method handles the allocation of digital paper pattern background and the creation of required page definition files embedded into digital paper enabled PDFs. Optionally, action palettes can be automatically overlaid on the drawings as legend boxes to enable field personnel to select the operations they want to perform on the digital paper as they would on a computer interface. For instance letting users select the types of callouts and clouds to add to their markup. These drawings can be printed or plotted onto paper and sent to a work site for markup.

System and method for document markup

A hand-holdable, durable digital writing and sketching device or assembly having rugged construction that houses an on-board camera with a view through an optical window of a writing surface brought in view by a user moving the device. The device is rugged, sealed, and is capable of withstanding dropping, water submersion, abrasive incursions, and resistance to chemical and fungal degradation. The optical window and optic channel to the camera is protected by a durable and replaceable light-transmitting shield that provides a sealed barrier to the environmental elements harmful to the functioning of the device. The writing and sketching device oscillates between a stowed and a deployed state. The deployed state includes the camera being in view the writing surface and the stowed state includes the camera being either masked from viewing the writing surface or aimed internally from viewing the writing surface. Other versions of the digital writing and sketching device include replaceable styli and pens that are removable and interchangeable with a sealed chamber in the device. The stylus point or pen ends are substantially in view of the on-board device camera. Signal transmissions communicated from the digital writing and sketching device convey pressures experienced by the inserted stylus or pens and are represented in proportion to a microprocessor based display that conveys changing field of view experienced by the on-board camera.

Durable digital writing and sketching instrument

The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention exemplifies that genes encoding GTP binding proteins in one plant can silence endogenous gene expression in a different plant.

Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation

The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.

Therapeutic uses of melanin

The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples. of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.

Growing community of inventors

Vacaville, CA, United States of America

David R McGee