University of Utah Research Foundation

Other

Cognetix, Inc.

University of Missouri

The Salk Institute for Biological Studies

Baldomero M. Olivera

Lourdes J. Cruz

David R. Hillyard

J. Michael Mcintosh

Ameurfina D. Santos

David R Hillyard

Baldomero M Olivera

Maren Watkins

J Michael McIntosh

Lourdes J Cruz

Robert M Jones

Richard T Layer

Julita S Imperial

Carl Thomas Wittwer

R Tyler McCabe

A Grey Craig

Elsie C Jimenez

John D Wagstaff

William R Gray

David Griffen

Jean E Rivier

Kirk M Ririe

Doju Yoshikami

Ki-Joon Shon

Richard Jacobsen

Michelle Grilley

Ameurfino D Santos

Randy P Rasmussen

Li-Ming Zhou

Craig S Walker

Gregory S Shen

G Edward Cartier

John Dykert

George P Smith

Clark Colledge

Ameurfina D Santos

Maren Marsh

Ameurfino O Santos

Virginia D Monje

Jamie K Scott

Richard A Myers

Fe C Abogadie

David Griffin

Robert Schoenfeld

J Michael Mcintosh

The invention relates to relatively short peptides (termed &#x3b1;-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

&#x3b1;-Conotoxin peptides

Alpha-conotoxin peptides

Apha-conotoxin peptides

A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such a DNA polymerase chain reaction. Biological samples are placed in glass micro capillary tubes and then located inside the sample chamber. A programmable controller regulates the temperature of the sample inside the sample chamber. Once a heating cycle is completed, the controller opens a door to the chamber for venting hot air out and cool ambient air is moved in. Temperature versus time profiles corresponding to optimum denaturation, annealing and elongation temperatures for amplification of DNA are achieved by the present invention.

Method for rapid thermal cycling of biological samples

A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such as the DNA polymerase chain reaction. Biological samples are placed in glass micro capillary tubes and then located inside the sample chamber. A programmable controller regulates the temperature of the sample inside the sample chamber. Monitoring of the DNA amplification is monitored by fluorescence once per cycle or many times per cycle. The present invention provides that fluorescence monitoring of PCR is a powerful tool for DNA quantification.

System and method for fluorescence monitoring

The invention relates to relatively short peptides (termed &agr;-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

&agr;-conotoxin peptides

A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such a the DNA polymerase chain reaction. Biological samples are placed in glass micro capillary tubes and then located inside the sample chamber. A programmable controller regulates the temperature of the sample inside the sample chamber. Once a heating cycle is completed, the controller opens a door to the chamber for venting hot air out and cool ambient air is moved in. Temperature versus time profiles corresponding to optimum denaturation, annealing and elongation temperatures for amplification of DNA are achieved by the present invention.

The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

O-superfamily conotoxin peptides

The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

Contulakin-G, analogs thereof and uses therefor

The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

Conantokins

Contulakin-G, analogs thereof and uses thereof

Growing community of inventors

Salt Lake City, UT, United States of America

David R Hillyard