Abbott Laboratories Corporation

Abbvie Inc.

Reservoir Management Services, LLC

David R Hill

Jianzhang Mei

Michael J Abrahamson

Kirill A Lukin

Russell Drew Cink

Marvin Robert Leanna

Timothy B Towne

Dennie S Welch

Gang Zhao

Kenneth M Engstrom

Richard D Bishop

Maureen Ann McLaughlin

Matthew M Ravn

Westin H Morrill

Matthew J Pelc

Jeff M Kallemeyn

Anthony Ralph Haight

Ravi Kurukulasuriya

Chi-nung W Hsiao

Elaine C Lee

Steve Wittenberger

David H Dolphin

Howard E Morton

Yi-Yin Ku

Sanjay R Chemburkar

James J Napier

Steven J Wittenberger

Jien-Heh J Tien

Steven A King

Daniel J Plata

David A Riley

Shashank Shekhar

Thaddeus Stephan Franczyk, Ii

Michael Rasmussen

Arthur J Cooper

Margaret Chi-Ping Hsu

Eric J Stoner

Rajarathnam E Reddy

Su Yu

Lei Wang

Dennis Duncan Earl

Anne E Bailey

Angelica B Kielbus

Prasad S Raje

Tim Grieme

Todd S McDermott

William T Riordan

Matthew John Peterson

Mukund S Chorghade

Mahendra N Deshpande

Gareth J Brown

Stefan Mix

Fumio Hino

Matthew J Peterson

David Riley

Sanford Burris

Marvin R Leanna

Maureen A Mclaughlin

Maureen Ann Mclauglin

Thaddeus S Ii Franczyk

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

Synthetic route to anti-viral agents

The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

Difluoroalkylcyclopropyl amino acids and esters, and syntheses thereof

Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid

A system makes real time fluid level determinations based upon shock waves detected by a pressure sensor which is able to detect very small changes in the amplitude of the received signal. Because the various components of the artificial lift system can have significant mechanical vibrations and noise, the pressure sensor utilized in the present invention may be high-sensitivity pressure sensor which is vibration-compensated with an electrical amplifier integrated directly into the sensor body to amplify the observed shock wave. The sensor has compensation components which ascertain low-frequency lateral motion and other noise, distinguishing the low frequency wave forms from the incoming reflections from the shock waves. The observed lateral motion is subtracted from the pressure sensor signal in determining the depth to the fluid.

Fluid level determination apparatus and method of determining a fluid level in a hydrocarbon well

A system for matching the hydrocarbon reservoir inflow with the outflow of an artificial lift system utilizes an apparatus which makes real time fluid level determinations and inputs the observed fluid levels into a processor which controls the speed of a motor which operates a subsurface pump, so as to increase hydrocarbon production. The apparatus which makes real time fluid determinations is installed such that a gas emission port and a pressure wave receiving port are placed within the tubing-casing annulus.

Tool for use in well monitoring

Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.

Processes to make apoptosis promoters

Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6-O-alkyl erythromycin.

9-hydrazone and 9-azine erythromycin derivatives and a process for making the same

The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

Process for the preparation of matrix metalloproteinase inhibitors

In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2&prime;-substituted and optionally 4&Prime;-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Process for preparing 6-o-substituted erythromycin derivatives

The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Process for the selective N-formylation of N-hydroxylamines

9-hydrazone and 9-azine erythromycin derivatives and a process of making

A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above method to toxicologic, pathologic, histopathologic, mechanistic or genotoxic testing in order to identify toxic and/or otherwise metabolically-active beneficial or detrimental individual metabolites.

Use of synthetic metalloporphyrins for preparation and prediction of

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Gurnee, IL, United States of America

David R Hill