Perlegen Sciences, Inc.

Cambridge Enterprise Limited

Other

University of California

University of Texas System

Leland Stanford Junior University

Syngenta Participations Ag

Syngenta Crop Protection, Inc.

Genetic Technologies Limited

Custom Millworking, Inc.

The Texas A&m University System

David R Cox

Bradley A Margus

Dennis G Ballinger

Doug Easton

Bruce Ponder

Nila Patil

Malek Faham

Siamak Baharloo

Stephen P A Fodor

Anthony J Berno

David A Hinds

Donald M Grosman

Glenn P Schiffmann

Richard M Myers

Albert De La Chapelle

Len A Pennacchio

Mark McCamish

Deana A Arnold

Anna-Elina Lehesjoki

Jesse Hsu

Mark A McCamish

Donald M Grossman

Dennis Ballinger

The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.

Computer systems and methods for genomic analysis

Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.

Markers for breast cancer

The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone.

Method for the protection of trees

Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.

Life sciences business systems and methods

Methods and systems for identifying biological marker-placebo effect correlations are provided. Clinical trial design and data analysis of clinical trial data is modified to accommodate marker-placebo effect correlations.

Methods and systems for identifying predisposition to the placebo effect

Removable door jamb assembly guard, guarded jamb assembly, and methods of controlling a doorway. The guard preferably covers the full length of the jamb assembly, and the full width of the jamb assembly between an outer trim element and the door-arresting surface. The guard has a central section, a door leg section, an outer leg section disposed outwardly of the central section, and optionally a transition section between the central section and the outer leg section. Preferred embodiments of the guard can be installed on a jamb assembly while a conventional door slab is mounted to the jamb assembly, and the door slab can be closed and opened without the guard interfering with such operation of the door slab.

Door jamb protector

Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and-lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

Mismatch repair detection

Improved pharmaceutical and diagnostic business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic development.

Pharmaceutical and diagnostic business systems and methods

Several methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value.

Methods for genetic analysis

The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.

Haplotype structures of chromosome 21

Methods for genomic analysis

Growing community of inventors

Belmont, CA, United States of America

David R Cox