Battelle Pulmonary Therapeutics, Inc.

Ventaira Pharmaceuticals, Inc.

Battelle Memorial Institute

Battellepharma, Inc.

Efield Innovations LLC

David R Busick

James E Dvorsky

Richard D Peters

Gregory A Trees

William C Zimlich

Theodore Robert Adams

William Godwin Atterbury

Chad Edward Bouton

James Henry Saunders

David Arthur Holley

Peter Andrew Gaydos

George C Proicou

Daniel Duane Meek

Daniel D Meek

An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.

Nozzle for handheld pulmonary aerosol delivery device

A container closure device for facilitating withdrawal of a liquid from a collapsible sealed packet is disclosed. The device includes a needle guide and a septum retainer wherein the needle guide is fixable to an outer face of the packet and the septum retainer is fixable to an inner face of the packet in alignment with the needle guide. The needle guide includes a tube for receiving a needle and insures proper alignment of the needle. The septum retainer includes a septum chamber having a septum disposed therein.

Drug containment system

A micropump comprising a pump body including a fluid inlet channel, a fluid outlet channel and pumping reservoir, the fluid inlet channel and the fluid outlet channel communicating with the pumping reservoir, a diaphragm covering the pumping reservoir, a piezoelectric strip actuator attached to the diaphragm such that by applying a voltage to the actuator, the diaphragm can be raised or lowered relative to the pumping chamber, a valve on the inlet channel and the outlet channel, the valve opening and closing the inlet and the outlet channel in response to the raising and lowering of the diaphragm.

Piezoelectric micropump with diaphragm and valves

A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.

Pulmonary aerosol delivery device and method

A electrohydrodynamic aerosol sprayer wherein a gas flow deflector is used for creating a gas flow past the spray nozzle to stabilize the Taylor cone and to transport at least a portion of the aerosol away from the region downstream of the spray nozzle. This stabilization of the cone and transport of aerosol improves the droplet size and distribution and may also reduce the deposit of droplets on the internal components of the device.

High mass transfer electrosprayer

Growing community of inventors

Lewis Center, OH, United States of America

David R Busick