International Minerals & Chemical Corp.

Angus Chemical Company

David R Bright

Vernon V Young

Robert D Williams

Jerome L Martin

Richard E Ivy

Ross G Brown

A process for promoting growth and feed efficiency in food producing mammals is provided by administering to such mammals, growth promoting amounts of a zinc complex of a polyether antibiotic selected from the group consisting of monensin, nigericin, salinomycin, narasin, noborotomycin A and B, SY-1, grisorixin, X-206, lonomycin, laidlomycin, mutalomycin, alborixin, lasalocid and lysocellin. Zinc complexes of this type are prepared by adding soluble zinc salt to a fermentation beer containing a polyether antibiotic to thereby form an insoluble, recoverable biomass containing the desired growth-promoting zinc complex for use in the process herein.

Process for promoting growth and feed efficiency of food producing

A process for promoting growth and feed efficiency in food producing animals is provided by administering to such animals, growth promoting amounts of certain forms of lysocellin, including the free acid and physiologically-acceptable salts thereof. Metal complexes of lysocellin can be prepared by adding the appropriate soluble metal salts to a fermentation beer containing lysocellin to thereby form an insoluble, recoverable biomass containing the desired growth-promoting metal salt complex of lysocellin for use in the process herein.

Lysocellin-containing feed efficiency-enhancing animal feed

A growth promoting and feed efficiency-enhancing amount of a lysocellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof is administered to a food-producing animal selected from the group consisting of ruminants, swine and poultry in a process for promoting growth and enhancing feed efficiency of such a food-producing animal. A feed supplement for a food-producing animal, the feed supplement being capable of increasing the rate of growth of the animal when supplied in the animal's feed on a regular basis during the animal's normal growth period, and which is also capable of enhancing feed efficiency of the animal, includes a mixture of a basal feed material for a food-producing animal selected from the group consisting of ruminants, swine and poultry, and a growth rate-increasing and feed efficiency-enhancing amount of a lyoscellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof.

Lysocellin-containing composition and process for promoting growth and

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating ingestations of the pinworms Syphacia obscelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Quinoxaline adducts useful as anthelmintics

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating ingestations of the pinworms Syphacia obcelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as cattle, sheep, swine and poultry. Soluble manganese salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired manganese antibiotic complex. This biomass, in a dried form, can be given orally to animals such as cattle, sheep, swine and poultry. The subject manganese complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lysocellin, etc.); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen-containing divalent pyrrole ethers (A-23187, etc.); glycolic monovalent monoglycoside polyethers (etheromycin, etc.); other polyether antibiotics including ionomycin, aabomycin, disnerycin, duamycin, BL-580, K-41, SF-1195, M-4164A, A-32887, 30,504RP, 38,986, 44,161, 47,433, 47,434 and 47,224. The above manganese complexes are also active agents for improving cardiovascular function in animals. Purified manganese-containing antibiotic complexes can be extracted from the biomass using suitable organic solvents, followed by crystallization or precipitation of the purified complexes. The purified products can be administered as boluses, subcutaneous implants, or as injectable preparations.

Manganese-containing antibiotic agents

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating infestations of the pinworms Syphacia obvelata and Aspicularis tetraptera in mannals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

An adsorbable fibrin excipient for active biochemical agents which enables controlled release of the biochemical agents when a fibrin pellet or other article containing the biochemical agent is implanted in an animal. Also contemplated are formable combinations of fibrin and other materials, such as lactose, to vary the absorption rate from the rate obtained using fibrin alone.

Fibrin binder/carrier for active biochemical agents

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating infestations of the pinworms Syphacia obvelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

A method for prophylactically and therapeutically treating mammals for the bacterial aspects of shipping fever caused by Pasteurella species prior to exposure, during incubation or during the symptomatic phase comprising parenterally administering to the mammal cycloserine in a dose sufficient to alleviate symptoms of shipping fever.

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Terre Haute, IN, United States of America

David R Bright