The Brigham and Women's Hospital, Inc.

David R Beier

Jeffrey M Drazen

James Grobholz

Koichiro Asano

Kwang-Ho In

Cherie Rao

Bruce Herron

Kevin P Brady

The present invention is directed to a mouse model of dilated cardiomyopathy in which animals are deficient in the expression of a gene encoding a p53 binding protein-related protein (PRP). The invention also encompasses the mouse PRP gene and protein themselves as well as counterparts found in the human. The various genes and proteins can be used in making transgenic animals and in assays designed to determine the likelihood of an individual developing cardiomyopathy.

P53 binding protein-related protein in cardiomyopathy

The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.

5-Lipoxygenase gene polymorphisms and their use in classifying patients

Identification of asthma patients who are candidates for effective

The invention pertains to osteoclast transporter proteins and genes encoding such proteins, as well as fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics involving the foregoing proteins and genes and agents that bind the foregoing proteins and genes, to influence osteoclast activity and bone remodeling.

Osteoclast transporter

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Brookline, MA, United States of America

David R Beier