Cornell University

Massachusetts Institute of Technology

Other

Cornell Research Foundation Inc.

Sewer Sentry LLC

David Putnam

Robert Samuel Langer

Daniel Griffith Anderson

David M Lynn

Mansoor M Amiji

Chung-Jr Huang

Jason Spector

Susana Mendez

Joseph Rosenthal

Jae-Young Kim

Jason A Spector

Matthew DeLisa

Lawrence J Bonassar

Steve Moore

Anne M Doody

Peter Zaweneh

Guido Quesada

Robert S Langer, Jr

Zhexun Sun

Daniel W Pack

Robert S Langer

Matthew Delisa

Alexander Zelikin

Nicole Ricapito

Shuicho Ando

Mingchee Tan

Christopher Sales

William Eugene Putnam

Kirk J Samaroo

Randall Avery Putnam

Mark Alfred Weih

The present solution can temporarily impart the handling characteristics of corneal stroma to the otherwise very thin, flimsy, coiling, and fragile Descemet membrane endothelial keratoplasty (DMEK) tissue during its insertion into the anterior chamber and positioning in apposition against the cornea of the recipient eye. The device of the present solution can be configured in a number of ways. In a first configuration, a scaffold can be coupled with the endothelial side of the DMEK graft. In a second configuration, the scaffold can be coupled with the stromal side of the DMEK graft. In a third configuration, one or more scaffolds can be coupled with both the endothelial and stromal side of the DMEK graft.

Temporary synthetic carrier for corneal tissue insertion and tissue delivery

The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.

Lubricating block copolymers and their use as biomimetic boundary lubricants

A valve assembly for use with and extending from an underside of a vented manhole cover assembly. The valve assembly is operable between an open position, to enable gas to exit from the manhole, and a closed position, to prevent the flow of the fluid into the manhole. The valve assembly includes a valve body having a first opening and a second opening and a fluid passage extending between the first and second openings. The valve assembly further includes a drain hole extending through the valve body configured to allow fluid drain therethrough. The valve assembly also includes a valve member moveable between the open position and the closed position, such that in response to the fluid entering through the first opening, the valve member moves from the open position to the closed position to prevent the flow of the fluid into the manhole, and wherein in response to fluid draining through the drain hole, the valve member moves from the closed position to the open position.

Vented precipitation guarding manhole cover assembly

A reinforced gasket for sealing a manhole, the gasket comprising a reinforcement ring having an upper surface and a generally planar lower surface; and a sealing assembly comprising a first ring and a second ring with an intermediate member extending between the first ring and the second ring, the intermediate member defining a contact surface; wherein the reinforcement ring is disposed between the first ring and the second ring of the sealing assembly such that the upper surface of the reinforcement ring is in contact with the contact surface of the seal ring.

Reinforced manhole cover gasket

A vented precipitation guarding manhole cover assembly, comprising: a manhole cover having a top exterior surface and a bottom interior surface; a vent opening extending through the manhole cover between the top and bottom surfaces; a valve assembly in fluid communication with the vent opening and extending from the bottom interior surface, the valve assembly configured to extend from the bottom interior surface at least partially inside the manhole, the valve assembly operable between an open position, to enable gas to exit from the manhole, and a closed position, to prevent the flow of fluid from the top exterior surface into the manhole.

Valve flapper

Cleanout conduit valve installations may include at least one cleanout housing having a cleanout housing interior and configured for placement in the cleanout conduit hole with the at least one cleanout conduit extending into the cleanout housing interior. A cleanout housing opening may overlie the cleanout housing interior. An openable cleanout housing door may be disposed in the cleanout housing opening. At least one cleanout conduit valve assembly may be configured to be disposed in fluid communication with the at least one cleanout conduit in the cleanout housing interior of the at least one cleanout housing. The at least one cleanout conduit valve assembly may include a valve housing configured for mounting on the at least one cleanout conduit. A valve mount may be carried by the valve housing. A valve may include a valve arm pivotally carried by the valve mount. A valve stop may extend from the valve arm. A valve body may be carried by the valve arm. The valve body may have a sealing surface. The valve may be positional between a closed valve position configured to seal the valve housing and a full open valve position configured to unseal the valve housing. The valve stop may engage the valve body in the full open valve position.

Cleanout conduit valve assemblies and installations

Cleanout conduit valve assemblies for a cleanout conduit may include a vertically oriented valve housing. The valve housing may include a valve inlet end configured to be disposed in fluid communication with the cleanout conduit and a valve discharge end opposite to and generally above the valve inlet end. The valve discharge end may be oriented within a valve discharge plane disposed at a discharge angle of greater than 0 degrees with respect to a horizontal plane. The valve discharge end may have an upper discharge opening side and a lower discharge opening side sloped downwardly from the upper discharge opening side. A valve body may be pivotally carried by the valve housing at the upper discharge opening side of the valve discharge end. Methods of preventing precipitation and runoff on a ground surface from entering a cleanout conduit connected to a sewer service line are also disclosed.

Sure-seal cleanout conduit valve assemblies and methods

Traffic-compatible vented precipitation guarding manhole cover assemblies may include a manhole cover having an exterior manhole cover surface and an interior manhole cover surface. At least one opening may extend through the manhole cover from the interior manhole cover surface to the exterior manhole cover surface. A flexible, resilient extension conduit having elastic recoil memory may extend from the exterior manhole cover surface at the at least one opening.

Traffic-compatible vented precipitation guarding manhole cover assemblies

The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.

Subunit vaccine delivery platform for robust humoral and cellular immune responses

Polymer compositions having the following chemical structure: wherein Lrepresents a polymeric linker having the structure shown connecting ethylene oxide oligomers and their use in surgical devices containing the above composition is also described.

Polymeric DHA-containing biodegradable compositions and surgical barrier devices made thereof

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.

Biomimetic boundary lubricants for articular cartilage

A wastewater pump station venting system includes at least one wastewater discharge conduit; a wastewater pump station having a station interior disposed in fluid communication with the wastewater discharge conduit; at least one fresh air inlet conduit disposed in fluid communication with the station interior; at least one gas vent conduit having a vent conduit inlet segment disposed in fluid communication with the station interior and a vent conduit outlet segment disposed in fluid communication with the vent conduit inlet segment; at least one vent air inlet conduit disposed in fluid communication with the gas vent conduit between the vent conduit inlet segment and the vent conduit outlet segment, the vent air inlet conduit disposed at an acute angle relative to the vent conduit inlet segment and an obtuse angle relative to the vent conduit outlet segment; at least one vent fan disposed in fluid communication with the vent air inlet conduit; and at least one power source electrically interfacing with the vent fan. A wastewater pump station venting method is also disclosed.

Wastewater pump station venting system and method

Growing community of inventors

Ithaca, NY, United States of America

David Putnam