Imperial Chemical Industries Limited

Harvard College

University of Leicester

David Pioli

Wolfgang Walter Schuch

Andrew James Greenland

Ian George Bridges

Simon W Bright

Melvyn Hollis

Andrew Merryweather

Dario Valenzuela

Pseudo-operator sequences may be located in (or inserted into) plant genomes and utilized to drive expression of foreign genes. These pseudo-operator sequences are nucleotide sequences which are present at a suitable location in a gene at which repressor binding will lead to inhibitation or enhancement of gene expression. The disclosed technique permits the design of altered specificity repressors, which bind the pseudo-operators.

Regulation of gene expression

The present invention relates to the regulation of gene expression which entails providing a pair of unlike proteins, with unlike DNA binding domains, which will associate to form a heterodimer and bind to appropriate asymmetric DNA binding sites and hence depress or increase expression of adjacent genes.

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Limm, United Kingdom

David Pioli