Other

Guilford Pharmaceuticals, Inc.

Johns Hopkins University

David Peter Nowotnik

Kam W Leong

Hai-Quan Mao

James Perry English

Zhong Zhao

Wenbin Dang

Hungnan Lo

Brian Fredrick Abeysekera

Robert Jean Marie Denis Pirotte

Wensin Dang

Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same

Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles and methods of using the same

Process for the preparation of radiohalogenated radiopharmaceuticals by an electrophillic substitution, preferably halogenodestannylation reactions, by the reaction of an organometallic substituted precursor, preferably a trialkyl tin substituted precursor, with a radioactive halogen, preferably a radioactive iodine, astatine or bromine composition, in the presence of a catalytically effective amount of an anion selected from the group consisting of bromide, chloride and nitrite anion in an acid medium with an oxidizing agent.

Process for the preparation of radiopharmaceuticals

Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I:

A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I below: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic, or heterocyclic residue; x is .gtoreq.1; and n is 3-7,500, and where the biodegradable terephthalate copolymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. In addition, compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

Biodegradable terephthalate polyester-poly (phosphonate) compositions,

Growing community of inventors

Kingsville, MD, United States of America

David Peter Nowotnik