University of London

Queen Mary & Westfield College

Synoptics Limited

King's College London

University of Exeter

David Perrett

Yuti Chernajovsky

Paul Graham Winyard

Bjarne Faurholm

Ahuva Nissim

Francesco Dell'Accio

Nanda Kishore Nayuni

Paul Ellwood

Richard Maskell

Alasdair Hayden Wright

Sarah Thompson

Stephen Mather

Laura Sullivan

Christopher Hughes

Soledad Cecilia Ruiz Antoli

Nanda Kishore Babu Nayuni

Valerie M Corrigall

Alastair Hayden Wright

Paul Winyard

Paul G Winyard

Gabriel S Panayi

Nanda Kishore Babu Nanyuni

The present invention provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

Antibody and use in diagnosis and therapy of arthropathies

An imaging system () and associated method for detection of protein contamination on a surgical instrument () that has been treated with a fluorescing stain, wherein fluorophors in the stain are capable of emitting light of an emitted type when both excited by light of an excitation type and in contact with a protein are provided. The system comprises a light tight chamber () for receiving the instrument (). Inside the chamber () are both visible light sources () and excitation light sources () for respectively illuminating the chamber with visible and excitation type light. A digital camera () is able to capture a first image of the instrument () as illuminated by the visible light, and a second image, of patterns of fluorescence produced by the fluorophors in the stain corresponding to protein contamination. The first and second images are combined to produce a composite image of the instrument () highlighting the areas of protein contamination. Associated software can be used to analyse the images so as to determine a level of protein contamination.

Imaging system and associated method for detection of protein contamination

The present invention relates to a stable protein and/or amino acid detecting composition that can be used as a reagent for in situ detection, such as on surfaces. The invention also relates to a method for detecting protein and/or amino acid on surfaces using the composition and kits comprising the composition.

In-situ reagent for detection of proteins

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London, United Kingdom

David Perrett