Croda International, Inc.

David Patrick Overy

Russell Greig Kerr

Fabrice Berrué

Fabrice BerruÉ

Use of pycnidione, epolone A, and epolone B as anti-dandruff actives either alone or in combination in anti-dandruff compositions, particularly shampoos and conditioners. The actives are particularly effective againstyeasts and. A method of obtaining pycnidione, epolone A, and epolone B from culturing ofis also described.

Anti-dandruff composition comprising pycnidione and epolone

Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective againstyeasts andwhich may cause dandruff. A method of obtaining the anti-dandruff actives from culturing ofsp. strain RKDO347 is also described.

Anti-dandruff compositions comprising a spirofuranone lactam tetramic acid derivative

A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective againstyeasts andwhich may cause dandruff. A method of obtaining the fumagillin derivative from culturing ofsp. strain RKDO347 is also described. 

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Carleton Place, Canada

David Patrick Overy