Schering Corporation

Merck Sharp + Dohme Corp.

Smugmug, Inc.

Awes.me, Inc.

David Parry

Timothy J Guzi

Michael P Dwyer

Kamil Paruch

M Arshad Siddiqui

Gerald Wayne Shipps, Jr

Yongqi Deng

Lianyun Zhao

Rumin Zhang

William T Windsor

Patrick J Curran

Charles W McNemar

Todd W Mayhood

Emma M Lees

Bobby Yang

Vincent Stewart Madison

Janeta Popovici-Muller

Alan W Hruza

Thierry Olivier Fischmann

Marc A Labroli

Jose S Duca

Don MacAskill

Aaron Meyers

Evan Deffley

Erik John Giberti

Nathan Cosmo Rahn

Kevin Boyd

Lee Shepherd

Mikkel Wilson

Brian Fenton

Ivy Tsai

Kaserin Tammie Kong-Santos

Andres Ruiz

A system and method for managing raw files are disclosed. A plurality of image files associated with one or more raw files that include respective metadata are evaluated. A set of one or more of the images files are grouped together based on matching the respective metadata. An asset file corresponding to the raw file and the grouped set of the image files are generated. The asset file are retrieved in response to a request from a user device. At least one of the image files in the grouped set are selected and a display of the selected image file is generated for rendering.

AI-powered raw file management

Embodiments disclosed herein generally relate to a method, system, and computer readable medium for generating a thumbnail for a media file. A web client application server receives the media file having metadata associated therewith. The web client application server generates an interest point area. The interest point area includes one or more interest points in the media file. The web client application server aligns a thumbnail area with respect to the interest point area. The web client application server displays a portion of the media file in the thumbnail area. The portion of the media file that is displayed includes at least a portion of the interest point area.

Metadata based interest point detection

In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits. 

Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

Methods for inhibiting protein kinases

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

High affinity quinoline-based kinase ligands

Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

High affinity thiophene-based and furan-based kinase ligands

Growing community of inventors

Mountain View, CA, United States of America

David Parry