Atrix Laboratories, Inc.

Sharpoint L.p.

Other

David P Vanderbilt

Richard L Dunn

Donald R Cowsar

James Perry English

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

Biodegradable in-situ forming implants and methods of producing the same

Biodegradable polyamides, useful as absorbable sutures and as controlled release binder materials, are prepared by condensing 4,4'-spirobibutyrolactone with a primary diamine, optionally in the presence of a nylon salt, leading to homopolymers containing lactam structural units, or to random copolymers.

Biodegradable polyamides for providing a controlled release therapeutic

Biodegradable polyamides, useful as absorable sutures and as controlled release binder materials, are prepared by condensing 4,4'-spirobibutyrolactone with a primary diamine, optionally in the presence of a nylon salt, leading to homopolymers containing lactam structural units, or to random copolymers.

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Birmingham, AL, United States of America

David P Vanderbilt