Abbott Laboratories Corporation

David P Sawick

Yi-Yin Ku

Sanjay R Chemburkar

Hemantkumar H Patel

Daniel A Dickman

Juliette K Busse

Albert V Thomas

James D Ratajczyk

Harry O Spiwek

Bhadra Shelat

Ramesh R Patel

John N Starr

The present invention provides a process for the preparation of a compound of formula ##STR1## wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation; and A is selected from optionally substituted carbocyclic phenyl.

Process for the preparation of arylalkynyl-N-hydroxyurea derivatives

A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante. The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.

Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]-

Method for separation of gibberellin mixtures

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Wildwood, IL, United States of America

David P Sawick