Bracco International Bv

Access Pharmaceuticals, Inc.

Plasma Technologies, LLC

David P Nowotnik

Kondareddiar Ramalingam

Adrian D Nunn

Karen E Linder

John P Pirro

Richard J DiRocco

William L Rumsey

Palaniappa Nanjappan

Dennis Curtin

Paul R Sood

Donald R Stewart

Sergiy Victorovych Shevchuk

Jeremy E Jacob

Christiane M Baud

Charles M Heldebrant

Eugene J Zurlo

Daniel G Moro

Howard Callahan

K Bruce Thurmond

Charles Heldebrant

Eugene Zurlo

Kenneth Bruce Thurmond, Ii

Richard J Di Rocco

Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of: salt fractionation, chromatography, ultrafiltration, diafiltration, solvent-detergent treatment, and sterile filtration. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.

Methods for extracting proteins from a blood-based material

The present invention relates to platinum complex chemotherapeutic compounds having the generic structure: wherein n is 0 or 1 and, preferably, one of R, R, Ror Ris a -(linker)-polymer group that may contain up to four additional platinum chelates.

Macromolecular platinum chelates

Stable, viscous, mucoadhesive aqueous compositions which are useful for the prevention and treatment of ulcerative, inflammatory, and/or erosive disorders of mucous membranes and/or the delivery of pharmaceutically active compounds to mucosal surfaces for topical treatment or transfer to the systemic circulation.

Liquid formulations for the prevention and treatment of mucosal diseases and disorders

Stable, viscous, mucoadhesive aqueous compositions which are useful for the prevention and treatment of ulcerative, inflammatory, and/or erosive disorders of mucous membranes, especially mucositis.

The present invention relates to amidomalonate O,O'&#x2014;Pt and N,O&#x2014;Pt chelates and methods of preparing them in essentially pure form.

O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes

Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

Rhenium and technetium complexes containing a hypoxia-localizing moiety

Ligands and metal complexes thereof

The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by itself without the incorporation of a therapeutic. The device of the present invention consists of a water-soluble adhesive layer, a non-adhesive, bioerodable backing layer and one or more pharmaceuticals if desired in either or both layers. Upon application, the device adheres to the mucosal surface, providing protection to the treatment site and localized drug delivery. The &ldquo;Residence Time&rdquo;, the length of time the device remains on the mucosal surface before complete erosion, can be easily regulated by modifications of the backing layer.

Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds

Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprising

Rhenium and technetium complexes containing a hypoxia localizing moiety

Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising

Diagnostic imaging methods using rhenium and technetium complexes

Novel compounds of the formula ##STR1## where G.sup.1 and G.sup.2 are each independently --OH or --N(R.sup.2).sub.2, provided that at least one of G.sup.1 and G.sup.2 is --N(R.sup.2).sub.2, where each R.sup.2 is independently hydrogen, alkyl, aryl, acyl or --(A).sub.p --R.sup.a and the other variables are as defined in the specification and claims, and novel complexes of these compounds with metals are useful in diagnostic and therapeutic methods.

Growing community of inventors

Flemington, NJ, United States of America

David P Nowotnik