Incyte San Diego Inc.

Ortho-mcneil Pharmaceutical Corp.

Calcimedica, Inc.

Maxia Pharmaceuticals, Inc.

David P M Pleynet

Catherine Tachdjian

Lyle W Spruce

Magnus Pfahl

Hussien A Al-Shamma

Andrea Fanjul

Jeffrey Paul Whitten

Soan Cheng

Gonul Velicelebi

Kenneth Stauderman

Torsten R Wiemann

Mohamed Boudjelal

Described herein are compounds and pharmaceutical compositions containing compounds of Formula (I), which modulate the activity of store-operated calcium (SOC) channels: wherein R, Rand Rare defined herein. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Compounds that modulate intracellular calcium

Described herein are compounds of Formula I and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also describe herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease 

Substituted heterocycles for the treatment of diabetes and other diseases

The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia: 

N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

Imidazolidinedione derivatives for the treatment of diabetes and other diseases

Thiazolidinedione derivatives for the treatment of diabetes and other diseases

Heterocyclic derivatives for the treatment of diabetes and other diseases

Growing community of inventors

San Diego, CA, United States of America

David P M Pleynet