Synphar Laboratories, Inc.

Taiho Pharmaceutical Company Limited

David P Czajkowski

Ronald G Micetich

Samarendra N Maiti

Paul Spevak

Charles Y Fiakpui

Kazuo Adachi

Andhe V Reddy

Narender A Reddy

A V Reddy

Harninder Atwal

This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as well as effective thrombin inhibitors and therefore are useful as anti-inflammatory, anti-degenerative and anti-thrombin agents.

2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory,

2-spiro (2'-spirocycloalkyl) cyclopropyl cephalosporin sulfone compounds, methods of treating patients for elastase inhibition, and processes for preparing such compounds.

2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as

Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I ##STR1## are provided which are useful as potent elastase inhibitors.

2-spirocyclopropyl cephalosporin sulfone derivatives

Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of the formula (I) ##STR1## are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthritis and emphysema.

2-spirocyclopropyl 4-acylcephems

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David P Czajkowski