Millennium Pharmaceuticals Limited

David P Cardin

Stepan Vyskocil

Paul D Greenspan

Tianlin Xu

Jeffrey L Gaulin

Christelle C Renou

Zhan Shi

Yongbo Hu

Masaaki Hirose

Kenneth M Gigstad

Takaharu Hirayama

Alexandra E Gould

Hong Myung Lee

Noriyuki Nii

Sean J Harrison

Hiroyuki Watanabe

Takashi Motoyaji

Benjamin Stone Amidon

Hiroyuki Kakei

This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R, R, o, R, and Rand subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease. 

Quinoxaline compounds and uses thereof

Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*is &#x2014;H or &#x2014;CH; and Y is Formula (II) or Formula (III), wherein Ris &#x2014;H, &#x2014;CHor Calkyloxycarbonyl; and R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.

Indole substituted pyrrolopyrimidinyl inhibitors of Uba6

This invention provides compounds of formula I: 

Heteroaryls and uses thereof

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Wilmington, MA, United States of America

David P Cardin