Millennium Pharmaceuticals Limited

David P Andrew

Paul D Ponath

Brian A Zabel

Lijun Wu

Nancy Ruffing-Graham

Brain A Zabel

Nancy Ruffing

The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR-9-6. The invention further relates to a method of modulating a function of GPR-9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.

Methods of treating inflammatory disease using antibodies which bind GPR-9-6

The invention relates to antibodies or antigen-binding fragments thereof which binds the chemokine mammalian TECK and inhibit binding of the chemokine to mammalian GPR-9-6. The invention also relates to host cells that produce such antibodies or antigen-binding fragments, kits comprising such antibodies or antigen-binding fragments and methods of use for such antibodies and antigen-binding fragments.

Anti-TECK antibodies and methods of use therefor

The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.

Anti-CCR4 antibodies and methods of use therefor

Methods of inhibiting GPR-9-6 function

Methods of identifying agents which inhibit GPR-9-6

Methods of identifying agents which bind GPR-9-6

Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function

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Waltham, MA, United States of America

David P Andrew