Makhteshim Chemical Works Ltd.

Adama Makhteshim, Ltd.

David Ovadia

David Leonov

Raya Sturkovich

Ernestine Mandler

The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed form the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80&#xb0; to 1300&#xb0; C., preferably, 90&#xb0; to 1000&#xb0; C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating an purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.

Process for the preparation of substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives

An improved process for the production of Diazinon substantially free of toxic by-products in high yield and very high purity which involves mixing 2-isopropyl-4-methyl-6-hydroxypyrimidine with solid sodium or potassium hydroxide in a ketone or ether solvent at a temperature of about 50.degree.-60.degree. C. until a homogeneous mixture is formed, adding diethylthiophosphoryl chloride to the homogeneous mixture, keeping the mixture at a temperature of 55.degree.-80.degree. C. until the reaction is complete, and separating the Diazinon formed.

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Omer, Israel

David Ovadia