Pronai Therapeutics, Inc.

Accuri Cytometers, Inc.

Michigan State University

David Olson

Neal Goodwin

Mina Patel Sooch

Collin Anderson Rich

Gholamreza Sheikhnehjad

Clement James Goebel

Gholamreza Sheikhnejad

Finny Mathew

Zarini Muhammad-Tahir

John Cunningham

Reza Sheikhnejad

The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.

Methods and compositions for the inhibition of gene expression

A method of extracting and analyzing a data set from a flow cytometer system of the preferred embodiment comprises the steps of (1) running a sample and saving all collected raw data, (2) viewing raw (or 'unmodified') data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified data, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified data, and exporting the saved data as many times as necessary and/or desirable.

User interface for a flow cytometer system

The invention includes a system and a method for capturing multi source excitations from a single location on a flow channel. The system preferably includes a light subsystem that emits light onto a single location on a flow channel, a detector subsystem to detect light emitted from the single location on the flow channel, and a processor to separate the detected light. The method preferably includes emitting light onto a single location on a flow channel, detecting light emitted from the single location on the flow channel, and separating the detected light.

System and method of capturing multiple source excitations from a single location on a flow channel

Methods and compositions for cancer therapy

Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to have both low end and high end sensitivity. Also described is a conductimetric assay device having a pre-capture zone to capture unbound analyte. The assay device overcomes the problem of flooding by the analyte.

Methods to increase dynamic range and improve quantitative analysis in rapid biosensors

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Ann Arbor, MI, United States of America

David Olson