American Cyanamid Company

David Noble

Richard A Fletton

Hazel M Noble

Neil Porter

John B Ward

Michael V Ramsay

Derek R Sutherland

Edward P Tiley

Brian M Bain

Oswy Z Pereira

Gordon C Lawrence

Michael J Dawson

Richard Bell

Stephen J Lane

Peter D Howes

Michael V Ramsey

Derek N Evans

Paul F Lambeth

Alison C Rosemeyer

Derer R Sutherland

Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;

Macrolide compounds

Compounds as described having the partial formula ##STR1## These compounds may have a 5-OH or --OMe group and at the 25- position an isopropylene group substituted by methyl, ethyl or isopropyl. The compounds may be used in agriculture or medicine as antiparasitics, and may be prepared by culturing certain Streptomyces strains, in particular Streptomyces thermoarchaensis NC1B 12015.

Strains of Streptomyces thermoarchaensis

Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof;

Compounds of formula (1) ##STR1## and their salts, wherein R.sup.1 is a methyl, ethyl or isopropyl group each substituted by a hydroxyl group or R.sup.1 is a group --(CH.sub.2).sub.n R7 or a group --CH(CH.sub.3)R.sup.7 (where n is zero or 1 and R.sup.7 l is CHO or CO.sub.2 H);

Compounds of formula (I) ##STR1## and salts thereof, wherein R is a C.sub.1-4 alkyl group, R.sup.1 is a methyl, ethyl or isopropyl group; and OR.sup.2 is a hydroxyl or substituted hydroxyl group having up to 25 carbon atoms. These compounds may be used for controlling insect, acarine, nematode or other pests.

Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;

A process for the preparation of a compound of formula (I) ##STR1## (in which R.sup.1 is methyl, ethyl or isopropyl) by hydrogenation of a corresponding compound having a double bond at the 22,23-position, for example in the presence of a rhodium catalyst.

Preparation of macrolide compounds

Compounds are described of formula (1) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;

Compounds are described of formula (I) ##STR1## and salts therof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;

Macrolide antibiotics

Compounds are described of formula (II) ##STR1## and salts thereof, wherein R.sup.1 reprsents a methyl, ethyl or isopropyl group;

Macrolide antibiotics and their preparation

Compounds are described of formula (I) ##STR1## and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R.sup.1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position. These compounds may be used for controlling insect, acarine, nematode or other pests.

Compounds as described having the partial formula ##STR1## These compounds may have a 5--OH or --OMe group and at the 25- position an isopropylene group substituted by methyl, ethyl or isopropyl. The compounds may be used in agriculture or medicine as antiparasitics, and may be prepared by culturing certain Streptomyces strains, in particular Streptomyces thermoarchaensis NC1B 12015.

Antibiotic compounds

Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group; and

Antibiotic compounds and method of use

Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 a methyl, ethyl or isopropyl group;

Growing community of inventors

Burnham, United Kingdom

David Noble