University of Michigan

Onl Therapeutics. Inc.

Massachusetts Eye and Ear Infirmary

David Noam Zacks

Cagri Giray Besirli

Alexander James Bridges

Francis X Smith

Linda Lea Johnson

John K Freshley

William A Hunke

Ethan Sylvain

Joan W Miller

Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.

Peptide compositions and methods of use

The present invention provides compositions and methods to prevent apoptosis. In particular, provided herein are compositions and methods which prevent FAS-mediated photoreceptor apoptosis.

Methods of inhibiting photoreceptor apoptosis by eliciting the Faim2 antiapoptotic pathway

The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis.

Methods of inhibiting photoreceptor apoptosis

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

Methods for preserving the viability of photoreceptor cells by anti-FAS-ligand/anti-FAS-receptor antibodies

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Ann Arbor, MI, United States of America

David Noam Zacks