American Cyanamid Company

David N Ridge

John W Hanifin, Jr

Yang-I Lin

Stanley A Lang, Jr

William D Dean

Robert F Church

An improved process for the large scale production of the compound (3.beta.,5.alpha.)-3-hydroxycholest-8(14)-en-15-one is described and two new compounds which have utility as intermediates in synthetic routes to the subject compound are disclosed.

Novel intermediates and an improved process for producing the compound

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted 1-phenyl-1H-1,2,4-triazoles and/or the pharmacologically acceptable acid-addition salts thereof.

Substituted 1H-1,2,4-triazoles

Isoxazolecarboxylic acid phenyl esters which are intermediates for the preparation of anti-inflammatory agents.

Substituted phenyl esters of isoxazolecarboxylic acids

This disclosure describes novel substituted 2-benzoyl-3-alkoxy-2-alkenonitriles and substituted 2-benzoyl-3-amino-2-alkenonitriles which are useful as intermediates for the preparation of certain substituted cis-2-benzoyl-3-hydroxy-2-alkenonitriles which possess anti-inflammatory activity.

2-Benzoyl-3-dimethylamino-2-alkenonitriles

Substituted-phenyl alkylidene acetoacetonitriles which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.

Substituted phenyl alkylidene acetoacetonitriles

Substituted phenyl-2-cyano-2-alkenoic acid esters which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.

Substituted phenyl-2-cyano-2-alkenoic acid esters

Substituted phenyl-2-cyano-2-thioalkenoic acid esters which are useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease.

Substituted phenyl-2-cyano-2-thioalkenoic acid esters

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being .beta.-oxo-3-thiophenepropionitrile, .beta.-amino-2-thiopheneacrylonitrile, and/or .beta.-amino-3-thiopheneacrylonitrile.

.beta.-Oxo-3-thiophenepropionitrile and

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted cis-2-[2(or 3)-thenoyl]-3-hydroxy-2-alkenenitriles and/or the pharmacologically acceptable cationic salts thereof.

Thiophenepropionitriles

.beta.-oxo-3-thiophene propionitrile and .beta.-amino-2-(3)-thiophene

2-Benzoyl-3-alkoxy-2-alkenonitriles

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted cis-2-benozyl-3-hydroxy-2-alkenonitriles and/or the pharmacologically acceptable cationic salts thereof.

Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory agents

This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said composition of matter being certain cis-2-benzoyl-3-hydroxy-2-alkenonitriles and/or the pharmacologically acceptable cationic salts thereof.

Growing community of inventors

Upper Grandview, NY, United States of America

David N Ridge