Calypso Medical Technologies, Inc.

University of Vermont and State Agricultural College

Medical Tactile, Inc.

D. Krag LLC

Krag, David N.

David N Krag

Lyn Oligino

Stephanie C Pero

Alan Irving West

Joel B Weinstein

Navin Dewagan

The invention provides methods and compositions for treating subjects using Grb7 antagonists. Specifically disclosed are Grb7 antagonists that bind selectively to Grb7 and interfere with the ability of Grb7 to bind to its native ligands. These compositions are useful in the prevention and treatment of disorders characterized by abnormal interaction of Grb7 with its native ligands (e.g., ErbB2).

Methods and compositions for inhibiting GRB7

The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).

Binding peptides specific for the extracellular domain of ErbB2 and uses therefor

A system and method for bracketing a tissue volume () and later locating the bracketed tissue volume. The system includes a plurality of markers () and a probe () and detector () for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool () is provided for removing the tissue volume, and a tissue anchor () is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.

System and method for bracketing and removing tissue

A system and method for bracketing a tissue volume ( ) and later locating the bracketed tissue volume. The system includes a plurality of markers ( ) and a probe ( ) and detector ( ) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool ( ) is provided for removing the tissue volume, and a tissue anchor ( ) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.

An apparatus obtains image data for a structure through bodily tissue. The apparatus includes an imaging sensor that contacts the bodily tissue to obtain image data for a first image of the structure. A pressure sensor is oriented in substantially a same direction as the imaging sensor and contacts the bodily tissue to obtain data for a second image of the structure. The second image is a different perspective of the structure than the first image.

Obtaining images of structures in bodily tissue

A method of stabilizing a tissue mass, using a system ( ) that includes temperature sensors ( ), a scanner ( ), and a cryoprobe ( ). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.

Method for stabilizing and removing tissue

A system (8) and method for stabilizing a tissue mass, using temperature sensors (10), a scanner (80), and a cryoprobe (220). The sensors provide temperature information with respect to a tissue portion adjacent thereto. The sensors include an identification (ID) code and an ID decoder. The ID decoder compares the sensor ID code to an ID code contained in an interrogation signal provided by the scanner. If the codes match, the sensor transmits the temperature information to the scanner, which processes and displays the temperature information in a humanly recognizable form. The method includes the step of inserting a cryoprobe into a tissue volume to be stabilized so that a portion of the cryoprobe projects therefrom. Then, the tissue volume is frozen while monitoring the size or temperature of the tissue volume. Freezing is terminated when the tissue volume is frozen (or reaches a first temperature level), and then removed while grasping the cryoprobe so as to stabilize the tissue volume.

Growing community of inventors

Shelburne, VT, United States of America

David N Krag