Fisons Ltd.

David N Hardern

John R Bantick

Thomas B Lee

Sidney C Burford

Martin E Cooper

David K Donald

Richard A Appleton

John Fuher

David J Wilkinson

Mark Furber

John Dixon

There are disclosed compounds of the formula (I): ##STR1## in which the variables R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and X are defined in the specification. The compounds are useful as pharmaceuticals, especially as anti-inflammatory agents.

Anti-inflammatory 4-aminophenyl derivatives

Macrocyclic compounds

There are described compounds of formula I, ##STR1## wherein R.sup.1 represents H or OH; R.sup.2 represents H; in addition, R.sup.1 and R.sup.2 may together represent a second carbon-carbon bond between the carbon atoms to which they are attached; R.sup.3 represents OH or OCH.sub.3 ; X represents O or (H,OH); and Y represents O or N--OR.sup.4, in which R.sup.4 represents H or alkyl C.sub.1-6 ; provided that when R.sup.1 is OH, R.sup.2 is H and X is O, then Y does not represent O. Processes for their production and compositions containing them, eg. for use as immunosuppressive agents, are also described.

There are described compounds of formula I, ##STR1## in which Ar.sub.1 and Ar.sub.2, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl or the pyridinyl each optionally being substituted by one or more of halogen; hydroxy; --COOR.sub.12 ; trihalomethyl; alkoxy C1 to 6; alkyl C1 to 6; --NR.sub.1 R.sub.2 ; alkoxy C1 to 6 substituted by --NR.sub.1 R.sub.2 or by phenyl; or alkyl C1 to 6 substituted by --NR.sub.1 R.sub.2 or by --COOR.sub.12 ;

4,5-dihydro pyrazole compounds

Pyrazoline compounds compositions and use

There are described compounds of formula I, ##STR1## in which either R.sub.2 represents hydrogen, alkyl or Ar.sub.2, and

Anti-inflammator 1,n-diarylpyrazol-3-amines

There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,

Naphthalene and 2-oxo-benzopyran acids and derivatives and

Compounds

The present invention relates to salts with basic amino sugars or basic amino acids of certain 2-carboxy or 2-tetrazolo-chromones.

Basic amino acid salts of chromones

There are provided processes for preparing compounds of the formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, and

Pharmaceutical compositions containing 4-carboxy-flavones

There are provided compounds of the formula: ##SPC1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, and X represents a hydrocarbon chain containing from 2 to 10 carbon atoms, optionally substituted by a hydroxy group) and pharmaceutically acceptable derivatives thereof. The compounds are antagonists of the slow reacting substance of anaphylaxis.

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Loughborough, United Kingdom

David N Hardern