Leland Stanford Junior University

Hyalex Orthopaedics, Inc.

The United States Government As Represented by the Department of Veterans Affairs

Biomimedica, Inc.

Vacu-site Medical, Inc.

Emergence Venture Partners, LLC

Santa Clara University

Verana Health, Inc.

David Myung

Lampros Kourtis

Michael J Jaasma

Curtis W Frank

Vernon Raymond Hartdegen

Daniel Chang

Robert Tienhan Chang

Alexandre Jais

Bing Yu

Timothy Sun

Christopher N Ta

Mark S Blumenkranz

Ira G Wong

Laura Hartmann

Alex Nugent

Lingmin He

Huynh P Van

Robert S Ward

Anthony J Abbate

Donald J Eaton

Keith R McCrea

Dennis R Carter

Stuart Barry Goodman

Edward E Manche

Jaan Noolandi

Won-Gun Koh

David Buickians

Michael Chad Hollis

Gary B Hulme

Michael E Hawkins

Iraklis Kourtis

Frank L Brodie

Jeffrey G Roberts

Sarah C Heilshorn

Benjamin Scott Arnett

Alan J Smith

Sarah Hull

James Craig Fryman

Beinn V O Mulr

Jaan Noolandl

Yin Hu

Michael R Carrasco

Mira Sahney

Hyun Jong Lee

Christopher Madl

Christopher Lindsay

Michael Mbagwu

David Nicholas Polkinhorne

Jean Noolandi

Curt Frank

An implantable artificial capsule and a method of implantation are provided. The implantable artificial capsule has a ring with a central opening to accommodate an intraocular lens and at least three haptic arms extending substantially orthogonal from the outer surface of the ring. Each arm has transcleral anchors for sutureless scleral fixation. Upon implantation of the implantable artificial capsule the arms are externalized trans-sclerally and atraumatically. The arms sit subconjunctivally. The implantable artificial capsule does not have any sutures for fixation and is suturelessly implanted in an eye, which is a major advantage as it significantly reduces complications during surgery and recovery.

Intraocular artificial lens capsule

Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

Polymeric adhesive for anchoring compliant materials to another surface

Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.

Compositions and methods for in situ-forming tissue constructs

Precise concentric, symmetric, and repeatable circular scoring (cutting) of Descemet's membrane is made possible by a handheld surgical ophthalmic device. The precision of the cut is provided by a stabilizing point on a stabilizing arm as well the anchoring insertion point at the limbus. Stabilization through the insertion point and the stabilizing arm provides a two-point fixation thereby establishing a cutting plane. The cutting plane allows for precise depth of cut whereas the rotating blade's consistent radius allows for circularity of the cut. The stabilization arm fixates on tissue, and is then removed when the procedure is completed. Consistent torque and contact pressure of the cutting blade is provided through rotational control via the depression of a button on a handle thereby removing the need to 'free-hand' the desemetorhexis.

Descemetorhexis creation device

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Multi-layered biomimetic osteochondral implants and methods of using thereof

Modular lens adapter system are provided for use with a hand held computer device having a camera for mobile ophthalmoscopy. The modular lens adapter systems include an anterior adapter and a posterior adapter configured to removably engage with a hand held computer device. The anterior adapter can include a variable intensity light source, a clamp, and a movable macro lens. The posterior adapter can include a hand held computer device mount, a lens mount, and a telescoping arm with a first end and a second end with the first end configured to removably engage with the mount and the second end configured to contact the lens mount. Methods are also provided for using the systems to obtain an image of an anterior portion of the patient's eye and a posterior portion of the patient's eye.

Modular adapters for mobile ophthalmoscopy

This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.

Vacuum-assisted drug delivery device and method

Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or composition gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.

Orthopedic implants having gradient polymer alloys

A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.

Modular lens adapters for mobile anterior and posterior segment ophthalmoscopy

Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or compositional gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.

Growing community of inventors

Santa Clara, CA, United States of America

David Myung