Celgene Corporation

Signal Pharmaceuticals, Inc.

David Mikolon

Heather K Raymon

Jeonghoon Sun

Shuichan Xu

John Frederick Boylan

Kandasamy Hariharan

Henry Chan

Dan Zhu

Mahan Abbasian

Laure Escoubet

Gustavo Fenalti

Monica Wai Ling Leung

Konstantinos Mavrommatis

Carlo Steven Santos

Christina Valerie Trout

Tao Shi

Ellen Filvaroff

Jennifer Riggs

Tam Minh Tran

Lilly L Wong

Robert Hubbard

Toshiya Tsuji

Gordon Bray

Andrew Wurmser

Gordafaried Deyanat-Yazdi

Provided herein are compositions, methods and uses involving antibodies that specifically bind to signal regulatory protein-α (SIRPα) and modulate the activity of SIRPα.

SIRP-α binding proteins and methods of use thereof

Provided herein are compositions, methods and uses involving antibodies that specifically bind to signal regulatory protein-&#x3b1; (SIRP&#x3b1;) and modulate the activity of SIRP&#x3b1;.

SIRP-&#x3b1; binding proteins and methods of use thereof

Provided herein are methods for treating or preventing a cancer, including solid tumors and hematological cancers, comprising administering an effective amount of aminopurine compounds of formula (I), and compositions comprising an effective amount of such compounds. 

Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I): 

Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof

Growing community of inventors

San Diego, CA, United States of America

David Mikolon