Pharmacyclics, Inc.

Leland Stanford Junior University

David Miklos

John C Byrd

Natarajan Muthusamy

Amy Jo Johnson

Jason A Dubovsky

Leonore A Herzenberg

Bita Sahaf

Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors. The methods include administering to an individual in need thereof an ACK inhibitor such as ibrutinib for treating and preventing graft versus host disease.

Methods of treating and preventing graft versus host disease

The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.

Method to detect the onset and to monitor the recurrence of chronic graft versus host disease in transplantation patients

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Stanford, CA, United States of America

David Miklos