Other

Allium Vitalis, Inc.

Banctec, Incorporated

David Michael Ott

James P Elwell

John W Wagner

Trent Quick

Paul Thomas Adair

Cynthia D Ott

Diane Ott

Chris A Harrison

Kenneth A Ott

Genetic and epigenetic diseases and disorders are treated with FDA approved dietary compositions in the form of dietary supplements and nutraceuticals. The diseases and disorders to be treated include Rett syndrome, trinucleotide repeat diseases such as Fragile X syndrome, memory impairment, chronic inflammation, pre-cancerous conditions which involve cancer stem cells, and post-cancerous conditions which involve cancer stem cells which have survived in spite of cancer treatment. Treatment options include prophylactic treatment which is initiated prior to the development of the symptoms of the disease or disorder.

Method of dietary treatment for genetic and epigenetic diseases and disorders

The present disclosure relates to the use of lipophilic mercaptans for the treatment of pain sensitization. The lipophilic mercaptans disclosed can be used to decrease the formation of protein-aldehyde adducts within nociceptive nerves, thereby reducing sensitization to pain.

Method of treatment for reducing pain sensitization

Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.

Method of decreasing protein-aldehyde adducts by administering a mixed disulfide of n-acetylcysteine and propyl mercaptan, propenyl mercaptan, or allyl mercaptan

Method of treating cancer by oral administration of acetate composition comprising magnesium acetate, calcium acetate or ethylacetate

On a motorized vehicle with handlebars and handlebar mounted levers, a motorcycle lever retention system includes a button operatively connected to and capable of toggling a rocker switch, a clutch or brake lever having a retracted position and an extended, biased position, a clutch or brake operatively connected to the clutch or brake lever such that the clutch is disengaged or the brake is engaged when the clutch or brake lever is moved into the retracted position, and a mechanism operatively attached to the rocker switch and configured such that when the button is pressed, the rocker switch is toggled causing the mechanism to prevent the clutch from being engaged or the brake from being disengaged and the clutch or brake lever from moving back into the extended, biased position until the button is pressed again.

Motorcycle clutch holding device

Organosulfur compounds for the prevention and treatment of neurodegenerative diseases

Organosulfur compounds and compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein aggregates, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, traumatic brain injury, stroke and cerebral ischemia.

Method of treating Rett syndrome by oral administration of acetate which is provided as composition comprising magnesium acetate, calcium acetate or ethylacetate

On a motorized vehicle with handlebars and handlebar mounted levers, a device includes a collar or clamp on which a thumb lever and catch slide in a groove to a desired position and are restrained by a notch, detent, slot, or other disruption in the groove to retain a handlebar lever in a desired position. Preferably, the thumb and catch are biased toward a disengaged position by a spring, by gravity, or by electro mechanical means. Spacers, additions, and handlebar extensions can all be provided with the device to allow for installation on a variety of handlebar sizes. In another embodiment, the thumb lever pivots about an axis generally perpendicular from the handlebar axis between a disengaged positon where the catch is clear from the clutch or brake lever and an engaged position where the catch engages the clutch or brake lever and holds it in a retracted position.

S-allylmercapto-N-acetylcysteine and related compounds are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compounds include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.

Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties.

Personal care and medicinal products incorporating bound organosulfur groups

A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to simultaneously enhance the host's ability to eliminate infectious microbes while suppressing the toxicity of the immune system response to the host. Allium related organosulfur compounds have a variety of antimicrobial and immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium related organosulfur compound such that a localized thiosulfinate is caused to be formed in response to localized generation of reactive oxygen species such as hydrogen peroxide by the activated immune system cells. Allium related organosulfur compounds may be administered to the host in an efficient manner through the use of protein-bound S-AllylMercaptoCysteine or similar prodrugs.

Organosulfur prodrugs for the prevention and treatment of infectious diseases

Nutraceutical and dietary supplement formulations for delivering bioavailable thiols to a host, comprising certain organosulfur radicals, such as the allyl mercapto radical, bound to larger molecules such as proteins, resulting in the formation in the host's body of various-related compounds such as allicin. The formulations are produced by treating an ingestible material comprising a cysteine-containing protein with a thiol, disulfide, mixed disulfide, thiosufinate or mixed thiosulfinate so as to cause thiol residues to become disulfide bonded to cysteines contained in the protein.

Medicinal products incorporating bound organosulfur groups

A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable thiol molecule that forms a membrane permeable disulfide molecule after becoming oxidized participates in thiol-disulfide exchange reactions on both sides of the cellular membrane, crossing the membrane randomly via simple diffusion. The membrane permeable disulfide, within or upon entering the highly reductive environment of a cell, becomes reduced to form a membrane permeable thiol molecule. the membrane permeable thiol can then diffuse to the exterior of the cell, where it is available to reduce another cystine molecule. This process can continue cycling, producing net cumulative increase in the concentration of extracellular cysteine. This is beneficial for providing cysteine as a nutrient to cells that require cysteine for nourishment.

Growing community of inventors

Oakland, CA, United States of America

David Michael Ott