Tokitae LLC

General Electric Company

David Michael Cate

Kevin Paul Flood Nichols

Bernhard Hans Weigl

David Roger Moore

Matthew Jeremiah Misner

Bing Li

Joshua Davis Bishop

Toan Huynh

Benjamin David Grant

Damian Madan

Caitlin E Anderson

Matthew F Rosen

Embodiments include assay devices within a single use, disposable cassette for biochemical assays with at least one fluid well and at least one capillary valve. The capillary valve in combination with motion of porous sheets within the assay leads to addition of liquid reagents at different times to the assay although a user adds the liquid reagents to the cassette simultaneously.

Assay structures for multi-step biochemical assays

A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

Device for rapid diagnostic tests to detect antigens with improved sensitivity

Growing community of inventors

Bellevue, WA, United States of America

David Michael Cate