Astrazeneca Ab

David Michael Andrews

Michael James Waring

Elaine Sophie Elizabeth Stokes

Andrew Turner

Clive Green

Maurice Raymond Finlay

Andrew John Barker

Zbigniew Stanley Matusiak

Clifford David Jones

Keith Hopkinson Gibson

Mark Andrew Graham

The invention concerns benzamide compounds of formula (I): compound of formula (I): wherein Ris a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from Calkyl, Ccycloalkyl, Calkoxy and Ccycloalkoxy;or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).

Benzamide compounds useful as histone deacetylase inhibitors

The invention concerns benzamide compounds of formula (I), wherein Ris a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from Calkyl, Ccycloalkyl, Calkoxy and Ccycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC). 

The invention concerns benzamide compounds of Formula (I), wherein R, R, R, R, R, R, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).

Benzamide compounds

Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Imidazo[1,2-A]pyridine having anti-cell-proliferation activity

Compounds of the formula (I), wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man. 

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Macclesfield, United Kingdom

David Michael Andrews