Givaudan S.a.

Givandan S.a.

David Max Dastrup

Stefan Michael Furrer

David C Bom

Ioana Maria Ungureanu

Thomas Scott McCluskey

Cooling compounds of formula (I) wherein Ris selected from the group consisting of hydrogen, methyl, C-Calkoxy, phenyl, C-Calkylphenyl, C-Calkoxyphenyl, thienyl, pyridyl, furyl, and indoyl;Ris selected from the group consisting of hydrogen and hydroxyl, orRforms together with the carbon atom to which it is attached a carbonyl group; andRis selected from the group consisting of 2,4-dimethylpent-3-yl, 2,3,4-trimethylpent-3-yl, adamantyl and 2-isopropyl-5-methyl-cyclohexyl-1-yl; and, product compositions comprising them.

Butone derivatives useful as cooling agents

A method of making a compound of formula II comprising the reaction of a compound of formula RCONHwith a compound of formula III R being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base. The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.

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Liberty Township, OH, United States of America

David Max Dastrup