Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

F. Hoffmann-la Roche Ag

David Mark Rotstein

Eric Brian Sjogren

David Michael Goldstein

Francisco Xavier Talamas

Sharada Shenvi Labadie

Chris Richard Melville

Stephen Deems Gabriel

Eun Kyung Lee

Jean-Marc Lapierre

Leyi Gong

Wylie Solang Palmer

Humberto Bartolome Arzeno

Bradley E Loe

Tania M Silva

Remy Lemoine

Jutta Wanner

Yun-chou Tan

Lubov Konstantinovna Filonova

Yun-Chou Tan

Erin M O'Brien

Lubov Filonova

Tania Silva

Inhibitors of JNK

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I. 

Heterocyclic antiviral compounds

This invention relates to piperidine derivatives of formula I wherein R, R, Rand Rare as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. Disorders that may be treated or prevented by the present derivatives include HIV and genetically related retroviral infections (and the resulting acquired immune deficiency syndrome, AIDS), rheumatoid arthritis, solid organ transplant reject (graft vs. host disease), asthma and COPD. 

Heterocylic antiviral compounds

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R-Rand Ar are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I. 

Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists

This invention relates to piperidine derivatives of formulae Ia and Ib with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. More particularly, the present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one and 1-oxa-3,9-diaza-spiro[5.5]undecan-2-one compounds and related derivatives, to compositions containing and to uses of such derivatives. Disorders that may be treated or prevented by the present derivatives include HIV and genetically related retroviral infections (and the resulting acquired immune deficiency syndrome, AIDS), diseases of the immune system and inflammatory diseases. 

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I. 

The present invention relates to certain pyrazole derivatives of Formula (I):that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Pyrazole derivatives-p38 MAP kinase inhibitors

The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.

Retinoid compounds (I)

Aminopyrrole compounds

Pyrazole derivatives P38 MAP kinase inhibitors

Pyrazole derivatives-p38 map kinase inhibitors

The present invention relates to certain pyrazole derivatives of Formula (I):

Pyrazole derivatives P-38 MAP kinase inhibitors

The present invention relates to certain 5-aroylnaphthalene derivatives of formula (I): ##STR1## that are inhibitors of prostaglandin G/H synthase, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

5-aroylnaphthalene derivatives as anti-inflammatory agents

Growing community of inventors

Sunnyvale, CA, United States of America

David Mark Rotstein