Other

University System of Maryland

David Margolis

Raphael J Mannino

Susan Gould-Fogerite

Robert R Redfield

Alonso Heredia

Linda Tadic

Diana Eppstein

David Oldach

Digital obsolescence avoidance systems and methods may determine an obsolescence vulnerability for a digital object. A digital obsolescence avoidance system may include a validation system and an obsolescence vulnerabilities system. The validation system may be configured to receive metadata for the digital object and to determine a digital object kind for the received metadata. The obsolescence vulnerabilities system may be configured to determine one or more dependencies for the determined object kind, to determine an obsolescence vulnerability based on the determined one or more dependencies, and to provide output related to the determined obsolescence vulnerability.

Digital obsolescence avoidance systems and methods

Synergistic combinations of guanosine nucleoside analog reverse transcriptase inhibitors such as abacavir with inosine monophosphate dehydrogenase inhibitors such as mycophenolates, pharmaceutical compositions comprising such combinations, and therapeutic methods comprising administering the synergistic combinations to subjects in need thereof, for treating a viral infection, such as an HIV-1 infection.

Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor

An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.

Integrative protein-DNA cochleate formulations and methods for transforming cells

Growing community of inventors

Baltimore, MD, United States of America

David Margolis