Mallinckrodt, Inc.

Mallinckrodt Medical, Inc.

Other

David M Wong

David H White

Youlin Lin

Mills T Kneller

Thomas J Dunn

Rebecca A Wallace

Robert L Hart

Mark E Bosworth

Richard G Johnson

Warren E Hall

Kevin Bartlett Graves

Narciso Ocampo Doran, Iii

Andrew M Schadt

Andrew Williams

Richard F Swenson

Randall H Quint

An automated bulk dispensing system and a method of use including selectively receiving a predetermined amount of radioactive liquid from a second container into a third container, selectively receiving a predetermined amount of nonradioactive liquid from a first container into a fourth container or directly into the third container depending on whether kits or multi-dose containers of medicine are desired. Preferably, this is for nuclear pharmaceuticals. Displacement mechanisms that are connected to the third container and fourth container are for mixing and dispensing liquid. There is at least one control valve, preferably three control valves, which are each controlled by drive mechanisms. The mixed liquid from the third container can be transferred to a recipient container. There is also a gas vent and bubble detector to eliminate bubbles with a processor that is also utilized to control the displacement mechanisms and the drive mechanisms.

Automated dispensing system and associated method of use

A sanitary sampling system for attachment to a tube portion of a fluid containing enclosure. The sanitary sampling system is comprised of a rigid stem portion for attachment to the tube portion of the fluid enclosure, a stopper portion having a lower portion for insertion into the rigid stem portion and tube portion, a disk-shaped orifice plate fitting for placement on the upper surface of the stopper portion and an adjustable clamp for adjustment around the stem portion, orifice plate fitting and stopper portions of the sanitary sampling system. The sanitary sampling system is designed to enable the stem portion, stopper portion and orifice plate fitting to interlock to form an air-tight and leak-free seal when the adjustable clamp is tightened.

Sanitary sampling system

The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals are purified by passing through a cross-linked reverse osmosis membrane.

Purification of X-ray contrast agent, magnetic resonance imaging agent,

An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.

Reversed phase chromatographic process

The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.

Purification of crude Ioversol using reverse osmosis

The present invention relates to chromatography column for process scale high performance purification, which has high stability and structural integrity regardless of the internal diameter or operating pressures. The chromatography column according to the present invention includes a sealing arrangement which enables the production of internally leak proof chromatography columns having large internal diameters at relatively low cost. The present invention also relates to the seal for the chromatography column.

Sealing arrangement for a chromatography column

Chromatography column with sealing arrangement

A sanitary packaging system and method of using the same for the packaging of a sanitary product comprising a sanitary housing portion, a product bag, a sliding adjustment tube and a product tube. The product tube extends inside the sanitary housing portion and is flexibly attached to the sliding adjustment tube to which the product bag is attached. The sanitary product under pressure passes through the product tube, sliding adjustment tube and into the product bag to complete packaging. Sanitized air is blown through the sanitary housing enclosure to create a positive pressure therein, whereby in the case of a leak within the product bag, sliding adjustment tube or product entry tube, sanitary product leaks outwardly therefrom rather than allowing contaminates to be pulled inwardly and contaminate said sanitized product.

Sanitary packaging system

A system for eluting a daughter radioisotope from a parent radioisotope and containerizing the resultant eluate in an evacuated container having a rubber stopper, providing for delivery of eluant from a reservoir through a tube to a generator containing the parent radioisotope, for venting of the reservoir to atmosphere via a tube, and for delivery of eluate from the generator via a tube to a tubular needle pierced through the stopper, with a cam-controlled hinged pinch plate for pinching the tubes closed.

Growing community of inventors

Chesterfield, MO, United States of America

David M Wong