Pendant Biosciences, Inc.

University of Toronto

David M Stevens

Christine Allen

Timothy Tordella Ruckh

Frantz Le Dévédec

Carl Eric Elmquist

Dean James Rager-Aguiar

Hilary Boucher

The present invention relates to a reservoir cover for use with hydroponic, aeroponic, aquaponic or similar systems used to cultivate plant articles without soil medium. The reservoir cover containing and re-directing water, nutrients, and other liquids, intentionally or un-intentionally leaked by the system, back into a reservoir or water source the reservoir cover is positioned upon. Within hydroponic, aeroponic, aquaponic or similar systems the plant article is held within a plant growing unit positioned above the reservoir cover. As water is dispersed from within said systems gravity directs movement of water, nutrients, and other liquids to the reservoir cover of the present invention. As water, nutrients and other liquids are leaked or lost from the plant growing unit the reservoir cover is positioned such that water, nutrients and other liquids are not dispersed to an undesirable location, but rather are re-directed back in the original water source or reservoir.

Hydroponic reservoir cover

The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer. In some embodiments, the compound can comprise amorphous networks. In some embodiments, the compound can include semi-crystalline networks.

Factors controlling drug release in cross-linked poly(valerolactone) based matrices

Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.

Crosslinked particles

Growing community of inventors

Frederick, MD, United States of America

David M Stevens