Corning Incorporated

Costar Corporation

Other

Data Packaging Corporation

David M Root

George F Lyman

Gregory Mathus

Nicholas Francis Borrelli

Raja Rao Wusirika

Bernard Eid

Alain R E Carre

Thierry L A Dannoux

William Joseph Lacey

David Butz

Gregory Roger Martin

Allison Jean Tanner

Joydeep Lahiri

Po Ki Yuen

Brian L Webb

Thierry L Dannoux

Keith A Horn

Jinlin Peng

Gilbert D Pujol

James George Clements

Mircea Despa

Paul E Gagnon

Michael Donavon Brady

John A Ryan

James B Stamatoff

Michael Curtis

Narayan V Iyer

Lewis Lawton

A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.

Multi-well plate and method of manufacture

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Microcolumn-platform based array for high-throughput analysis

A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.

Multi-well assembly for growing cultures in-vitro

Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate. In another embodiment, the device may be used in transferring sample between multiwell plates of different well density.

Redrawn capillary imaging reservoir

The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a membrane. The membrane is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e.g., hazardous chemical) which originally entered the sensor through a passage in the top cap and interacted with the membrane.

Sensor and method for detecting an air borne or exogenously introduced analyte

A support plate and method of making a support plate for biological or chemical testing or cell culture. The plate has a high density network of microwells formed therein. The wells are formed by a contact pressing technique whereby a network of protuberances are pressed into the surface of a thermoformable material.

High density test plate and process of making

A laboratory research tool for conducting a variety of procedures including cell and tissue culture techniques includes a multi-well cluster plate, a filter plate that has one or more filter wells that extend into the wells of the cluster plate, a cover and a reservoir that can be used with auxiliary equipment designed for use with standard 96-well format cluster plates. The system allows multiple tissue samples to be grown and manipulated simultaneously.

System for growing and manipulating tissue cultures using 96-well format

The present invention features hydrophobic articles of manufacture having a composition comprising a plastic and a fluoropolymer. The plastic-fluoropolymer composition is resistant to irradiation allowing the article to maintain hydrophobic properties through standard irradiation processes.

Sterile irradiated hydrophobic pipette tip

The present invention relates to an apparatus for growing tissue culture in vitro. The apparatus features a housing which fits into a well containing media. A bottom membrane surface is maintained at a depth within the well, and the housing centered in the well by a flange and rim which cooperate with the well.

Apparatus for growing tissue cultures in vitro

A tissue or cell growth device is described for placement within a well of a cluster dish. The device has a cell or tissue retention element detachably attached to a hanger. The hanger preferably has openings allowing access to the well without removal of the member and is capable of positioning the cell or tissue retention element a preselected distance relative to the hanger. Also described are various embodiments of the device having differently shaped hangers and the combination of the device and a cluster dish.

Culture device and method of use having a detachable cell or tissue

Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a tubular support that in turn hangs by a flange connected to its upper end on the top of a well containing the nutrients. Typically, the well is part of a tissue culture cluster dish. The flange of the support positions the support and membrane centrally in the well so as to avoid capillary action in the space between the well and support. The configuration of the support and its cooperation with the lid of the cluster dish also prevents the support and membrane from floating in the nutrient solution in the well. Openings in the support provide access for a pipette to add and withdraw fluid from the space between the well and membrane support and from the space below the membrane.

Growing community of inventors

Westford, MA, United States of America

David M Root