Life Technologies Corporation

Cygnus, Inc.

Applied Biosystems, LLC

Aprex Corporation

David M Liu

Joshua Mead

Albert L Carrillo

Alexander V Dukhovny

Peng Li

Joseph A Lazur

Joon Mo Yang

Kirk M Hirano

Mark F Oldham

Charles Stuart Vann

Joy Roy

Dennis Lehto

Ian A Harding

Nigel P Beard

Yuh-Min Chiang

Umberto Ulmanella

Alexander A Dromaretsky

Sergey V Ermakov

Pravin L Soni

Jon A Hoshizaki

Patrick D Kinney

Gary Lim

Maryam Shariati

John R Van Camp

Min Yue

Qiang Chen

Thomas E Conn

Michele Elizabeth Wisniewski

Norman A Parris

Victor H Yee

Michael Reidy

Richard G Hamilton

Michael J Butler

Christine M Wu

Brian S Kersten

John Van Camp

Capillary electrophoresis cartridge

Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Systems and methods for multiple analyte detection

Assemblies for and methods of coupling a microtiter plate and receptacle for centrifugation of liquid from the microtiter plate to the receptacle are provided. In some embodiments, a coupling frame can be used. In other embodiments, the microtiter plate couples directly to the receptacle. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-y plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-z plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the y-z plane.

Methods and assemblies for collecting liquid by centrifugation

Devices and methods are described for improving the contact of a conductive material, for example, a hydrogel, with a sensor, for example an electrode, by means of using mechanical force to apply the conductive material to the sensor before use of the conductive material and sensor in a sampling device. The device and methods of the present invention improve the sensor response characteristics in transdermal sampling devices placed in operative contact with a skin or mucosal surface of a biological system to obtain a chemical signal associated with an analyte of interest.

Device and methods for the application of mechanical force to a gel/sensor assembly

An automated system for continual transdermal extraction of analytes present in a biological system is described. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes. The present invention describes quality control test kits, and methods of use thereof, for testing the ability of the system to provide reliable, effective, and accurate determination of analyte concentration.

Kit and method for quality control testing of an iontophoretic sampling system

Cover for quality control testing of an iontophoretic sampling system

Device for the application of mechanical force to a gel/sensor assembly

A device for detecting the dispensing of drugs from a container in a way which eliminates false detection events due to mishandling of the container is disclosed. The device includes a container which may be opened and closed. It also contains a means for detecting the opening and separately detecting the closing of the container as well as means for measuring the time between these events and comparing this elapsed time to a predetermined standard indicative of drug dispensing event. The times of proper drug dispensing events are stored in the device for use by the health care professional following the patient's drug dosing compliance. Other opening and closing intervals which fall outside this time range give rise to an alternative response. They may be recorded with a notation of their probable error or they may be disregarded. In other aspects, the invention provides a preferred physical configuration for the electronic components of the device and a preferred means for accessing the data stored in the device.

Drug dispensing event detector

Growing community of inventors

Los Altos, CA, United States of America

David M Liu