Northwestern University

Quidel Corporation

Other

California Institute of Technology

Abbott Laboratories Corporation

Smiths Detection-pasadena, Inc.

Minute Molecular Diagnostics, Inc.

David M Kelso

Kunal Sur

Zaheer Parpia

Tom Westberg

Sujit Rao Jangam

Sally M McFall

Victor I Lyamichev

Nathan S Lewis

Lloyd M Smith

Robert Elghanian

Bruce P Neri

Jeff G Hall

Erik J Severin

Mark James Fisher

Beth C Munoz

Robert W Kwiatkowski, Jr

Bernard Wong

Priscilla Wilkins Stevens

Jennifer Lynn Reed

Ashley Marie Yanchak Boggiano

Samuel John Pickerill

Arman Nabatiyan

Abhishek K Agarwal

Shivani Gupta

Lawrence Markus

Reddy Reddy Reddy

Jacqueline R Groves

Matthew Austin Butzler

Abhishek Mathur

Douglas Yamada

Ashley Danielle Cramer

Sur Kunal

Sally Mcfall

Matthew A Butzler

Lawrence W Markus

Ashley D Cramer

Provided herein are devices and methods for the rapid processing and analysis of samples. In particular, a small-volume sample (e.g., nucleic acid sample) is exposed to (e.g., contacted with) different temperature zones within a device to process (e.g., amplify) and/or analyze (e.g., quantitate) the sample in an assay.

Devices and methods for rapid sample processing and analysis

Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.

Trans-interfacial magnetic separation

Provided herein are devices, systems, and methods for specimen preparation by employing a combination of capillary and centrifugal forces. For example, provided herein are devices, systems, and methods that collect a sample by capillary force, separate components of the collected sample by centrifugal force, and isolate one or more of the separated components by further capillary force.

Devices, systems, and methods for specimen preparation using capillary and centrifugal forces

Devices for use in extracting an analyte of interest from a sample are described. In one embodiment, a device is comprised of a first plurality of chambers, where one or more chambers in the plurality of chambers has a deep end and a shallow end with a depth d. A channel disposed between at least two adjacent chambers in the plurality of chambers has a depth greater than d. The dimensions of the chamber and channel provide control of fluid movement in the device, particularly when introducing fluid into the device for its use and during use of the device.

Device with controlled fluid dynamics, for isolation of an analyte from a sample

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input.

Devices and methods for filtering blood plasma

A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described.

Device for isolating an analyte from a sample, and methods of use

A device for collecting, treating and dispensing a biological sample is described. Use of the device permits integration of sample collection, sample treatment, and sample dispensing.

Methods and devices for sample collection, treatment and dispensing

The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.

Barriers for facilitating biological reactions

The present invention relates to compositions and methods for isolating and purifying nucleic acid. In particular, the present invention relates to methods of isolating nucleic acid from cells for use in further analysis.

Methods and compositions for isolating nucleic acid

This invention relates to a system and method related to an epifluorescence microscope based optical system equipped with a tunable filter to localize microspheres in bead-based assays based on a back-scattered light (also known as reflected light) image. A common optical path for reflected and emitted luminescence in conjunction with a tunable filter negates the requirement of an additional sensor employed in existing technologies for localizing microspheres based on light scatter measurements.

Systems and methods to analyze multiplexed bead-based assays using backscattered light

The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and modifying nucleic acids. For example, in some embodiments, the 5' nuclease activity of a cleavage agent is used to cleave a cleavage structure formed on the solid support, the occurrence of the cleavage event indicating the presence of specific nucleic acid sequences.

Solid-phase reactions

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Wilmette, IL, United States of America

David M Kelso