Kensey Nash Corporation

The General Hospital Corporation

The Charles Stark Draper Laboratory, Inc.

Other

Children's Medical Center Corporation

David M Hoganson

John E Nash

Douglas G Evans

Jeffrey T Borenstein

Joseph P Vacanti

Howard I Pryor

Ira Spool

Peter E Hammer

Pedro J Del Nido

John H Brekke

Scott M Goldman

Gino Bradica

Sitaram Emani

Mossab Y Saeed

Ravi K Veeraswamy

Christopher W Baird

Methods, systems, and cooptation measurement devices as described herein include an elongate sensor body at the end of a proximal connecting member, and a plurality of sensors in an array across a face of the sensor body, wherein each sensor of the plurality of sensors is configured to detect if a portion of a heart valve is in contact with the sensor.

Valve coaptation measurement devices

A repair device for closing a valve of a heart includes a main stem. The mains stem has a distal end and a proximal end. The main stem comprises a papillary anchor on the proximal end. The papillary anchor of the main stem is configured to attach to a papillary muscle of the heart. The main stem further includes a first branch extending from the main stem in a first direction and configured to attach to a first leaflet of the valve of the heart. The main stem also includes a second branch extending from the main stem in a second direction different from the first direction and configured to attach to a second leaflet of the valve. The first and second branches are flexible.

Repair device for heart valve repair

Methods, systems, and coaptation measurement devices as described herein include an elongate sensor body at the end of a proximal connecting member, and a plurality of sensors in an array across a face of the sensor body, wherein each sensor of the plurality of sensors is configured to detect if a portion of a heart valve is in contact with the sensor.

A dilator system for arterial and venous cannulas, where there is a smooth transition between the dilator and the outer wall of the cannula. One aspect of the subject technology provides a blunt-tip cannula that is used as a dilator for insertion of an arterial or venous cannula. The balloon might either be a single diameter or may have a larger diameter at the distal portion such that the diameter of the distal portion of the balloon dilator matches the diameter of the cannula at the tip. Another aspect of the subject technology is a balloon dilator for cannulae that may be positioned over a guidewire, for guidewire-directed placement of a cannula within a vessel, duct, lumen or heart structure of the body. Another aspect of the subject technology is an inflation system for the balloon dilator, such that the balloon dilator may be deflated and quickly removed from the cannula after the cannula has been positioned and secured within the vessel, duct, lumen or heart structure. Another aspect of the subject technology includes a stiffening element in the balloon dilator along its shaft to increase the rigidity of the combined balloon dilator and cannula to provide improved ease of insertion. Another aspect of the subject technology is an improved curvature of the shape of the right angle dilator that achieves more uniform flow within the dilator and ease of insertion and more even flow within the cannula, and ease of insertion of and retraction of the balloon dilator. Another aspect of the subject technology is a gel-filled balloon dilator that improves ease of insertion of the cannula within the vessel, duct, lumen or heart structure, and can be removed without deflation.

Balloon dilator

The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

Biomimetic vascular network and devices using the same

The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.

System and method for in vitro blood vessel modeling

The imperfect hemodymamics and non-endothelialized surface of the BT shunt and RV-PA conduit can be improved by utilizing a shape that has more uniform flow and lower shear stress. Accordingly, the shunt will have an acute takeoff angle with a fluted inlet portion that eliminates fluid separation and maintains the shear stress within or near the physiologic range. The distal aspect of the shunt may be fluted in one or both directions along the pulmonary artery to improve the flow transition and reduce the shear forces on the posterior wall the pulmonary artery. An autologous umbilical vein may be used as the shunt with fluted proximal and distal portions with an autologous endothelialized surface to minimize platelet deposition and thrombus formation. The umbilical vein shunt may have an external support for diameter constraint and maintaining the hemodynamically optimized fluted design.

Hemodynamically optimized shunt

A device for accessing a vessel, duct or lumen, comprising a guidewire having a proximal end and a distal end, and at least one projection that extends from said guidewire at or near the distal end of the guidewire. When the guidewire is placed into the vessel, duct or lumen containing a flowing fluid, the drag on the guidewire is greater when the fluid is flowing from the proximal to distal end of the guidewire than it is when it is flowing distally-to-proximally, thereby helping to direct the guidewire. The device is particularly useful in crossing a narrowing in the vessel, duct or lumen, such as may occur in blood vessels containing a stenosis, such as due to atherosclerosis.

Flow directed guidewire

An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. In one embodiment, the device is arranged for the local delivery of therapeutic agent. A preferred embodiment is a porous resorbable implant, wherein the therapy delivery may be localized in nature, rather than systemic, such that higher doses at the target site may be allowed than would be tolerable by the body systemically.

Resorbable polymeric device for localized drug delivery

A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures.

Growing community of inventors

St. Louis, MO, United States of America

David M Hoganson