Carbylan Therapeutics, Inc.

Angiotech International Ag

Poly-med, Inc.

Angiodevice International Gmbh

Angiotech Pharmaceuticals (us), Inc.

Pmidg, LLC

Angiotech Pharmaceuticals, Inc.

Carbylan Biosurgery, Inc.

David M Gravett

George Y Daniloff

Philip Michael Toleikis

Pingren He

Olof Mikael Trollsas

William L Hunter

Richard Tom Liggins

Michael Scott Taylor

Jacqueline Anne Schroeder

Seth Dylan McCullen

Michael Aaron Vaughn

Louis C Sehl

Michael Ngo

James Hyde

Brad Johns

Troy A E Loss

Brian Gaerke

Robert C Spiro

Dechi Guan

Prabhjot Saini

Kara Bethany Acampora

Arpita Maiti

Aniko Takacs-Cox

Rui Avelar

Patrick J Hillas

Philip M Toleikis

Pierre E Signore

Leanne Embree

T Richard Liggins

Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.

Functionalized and crosslinked polymers

Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away front the printed part, resulting in a part having surface cavities.

Polymers for additive manufacturing

Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

Modified hyaluronic acid polymer compositions and related methods

The present application provides rapid-gelling, sprayable hyaluronic-acid based compositions, kits, related methods, precursor formulations, and uses thereof.

Rapid in-situ gel forming compositions prepared via reaction of vinyl sulfone derivatized hyaluronic acid with thiol derivatized polyethylene glycol at alkaline pH

Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

Kit for multifunctional compounds forming crosslinked biomaterials

Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

Drug delivery from rapid gelling polymer composition

The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are capable of hydrogel formation.

Sterile hyaluronic acid polymer compositions and related methods

Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.

Polymer formulations for delivery of bioactive agents

Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use

Growing community of inventors

Mountain View, CA, United States of America

David M Gravett