Oncometrics Imaging Corp.

Accumed International, Inc.

Monogen, Inc.

Perceptronix Medical, Inc. and British Columbia Cancer Agency

David M Garner

Branko Mihael Palcic

Calum E MacAulay

S Alan Harrison

Bruno W Jaggi

Peter William Payne

Stephen C-t Lam

Gary William Ferguson

Mario Zganec

Jaka Lavrencak

Margareta Flezar

Alexei Doudkine

Paul Pong-Shing Lam

Alexei K Doudkine

Donald J Dale

Daniel B Harrison

Chun M Louie

Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of malignancy-associated changes (MAC) in cells, which can be used for the detection of cancer. The programs and methods detect cancer in one tissue by detecting MAC in another tissue, such as associated tissues or non-associated tissues. Examples of associated tissues include nipple aspirates or ductal washings to detect breast cancer, and sputum or bronchial lavage to detect lung cancer. Examples of non-associated tissues include buccal mucosa to detect lung or breast cancer.

Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer

A method for detecting malignancy-associated changes. A sample of cells is obtained and stained to identify the nuclear DNA material. The sample is imaged with a digital microscope. Objects of interest are identified in the sample of cells based on the intensity of the pixels that comprise the object versus the average intensity of all pixels in the slide image. An exact edge is located for each object and variations in the illumination intensity of the microscope are compensated for. A computer system calculates feature values for each object and, based on the value of the features, a determination is made whether the cell exhibits malignancy-associated changes or not.

Method and apparatus for automatically detecting malignancy-associated changes

A system and method for detecting diagnostic cells and cells having malignancy-associated changes are disclosed. The system includes an automated classifier having a microscope, camera, image digitizer, a computer system for controlling and interfacing these components, a primary classifier for initial cell classification, and a secondary classifier for subsequent cell classification. The method utilizes the automated classifier to automatically detect diagnostic cells and cells having malignancy-associated changes. The system and method are particularly useful for detecting these cells in cell samples obtained from bronchial specimens such as lung sputum.

System and method for automatically detecting malignant cells and cells

A composition and method for staining cellular DNA are disclosed. The composition of the present invention is an aqueous alcoholic solution that includes a cationic stain, a metabisulfite, and an alcohol preferably selected from methanol, ethanol, and mixtures thereof. In a preferred embodiment, the cationic stain is thionin.

Composition and method for staining cellular DNA, comprising thiazine

Method and apparatus for automatically detecting malignancy-associated

Apparatus for manually controlling a motorized microscope stage for movement about the X, Y and Z axes. The apparatus includes a main housing having an X axis control knob and a Y axis control knob rotatably mounted to the housing. A Z axis control knob is provided for controlling movement about the Z axis. The Z axis knob is mounted to a removable module so that the position of the Z axis control knob is adjustable with respect to the other knobs. There is a controller for generating stage control signals in response to movement of the knobs. A plug-in connector connects the apparatus to the microscope stage controller such that the stage control signals create corresponding movements of the motorized stage. The apparatus simulates the controls of a nonmotorized stage while maintaining compatibility with existing stage controller units. The apparatus is designed to provide tactile position feedback to the user similar to that of a manual non-motorized microscope.

Personal interface device for positioning of a microscope stage

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Vancouver, Canada

David M Garner