Chemgen Corporation

Other

Enzon Labs Inc.

Eli Lilly and Company

Smithkline Beecham Corporation

Enzon, Inc.

Elanco US Inc.

Genex Corporation

Ajinomoto Co., Ltd.

Glaxo Group Limited

The United States of America As Represented by the Department of

British Technology Group USA

U.s.a. Dept. of Agriculture

David M Anderson

Lin Liu

Robert L Strausberg

Susan L Strausberg

Sergey Podkovyrov

Douglas W Fodge

Kathy J Maugh

Humg-Yu Hsiao

Tena Wei

Jon Edward Ferrel

Russell J McCandliss

Yuefang Huang

Kurt Schuster

David R Filpula

Harry D Danforth

Michael D Ruff

Patricia C Augustine

Steven D Geusz

Baomin Wang

Thomas M Pettey

Russ McCandliss

Jeffrey C McGuire

Andrew John Collis

Christopher Preston

Klaus M Herrmann

Ronald L Somerville

Methods for reducing the environmental impact of animal waste are described. In particular embodiments, the methods comprise administering to an animal an enzyme, such as alkaline phosphatase, that is effective to reduce the amount of a detrimental compound, such as ammonia or phosphorous, that is present in or released from animal waste. Also provided is a method for increasing phosphorus digestion in an animal. Compositions suitable for use in such methods are also described.

Methods and compositions for reducing the environmental impact of animal waste

Compositions suitable for oral administration to an animal comprising at least one immune stress-reducing enzyme in an amount effective to decrease the level of positive acute phase protein in an animal, increase the level of negative acute phase protein in an animal, and/or improve animal growth performance is provided, as are methods using such compositions. The compositions include animal feed compositions, liquid compositions other than animal feed, and solid compositions other than animal feed.

Enzymes for reduced immunological stress

Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Biological production of thymidine

Enzymes of a particular class, characterized by the ability to cleave a linkage that effects release of a cell-surface protein or carbohydrate, which does not contain an anti-infection agent, display significant anti-infectious activity. Upon oral administration, these enzymes are effective, for example, in the treatment of digestive tract infections in humans and in animals. In the latter, there are benefits of significantly improved growth rate, feed efficiency, and overall health.

Composition comprising beta-mannanase

Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In preferred embodiments the constructs comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin further comprise DNA sequences encoding for thymidylate synthase and/or transcription units comprising sequences encoding for uridine kinase preferably together with dCTP deaminase. In particularly preferred embodiments, the host cells comprise constructs having all of the above characteristics wherein the host cell displays repressed or no uracil DNA glycosylase activity. This may be achieved by removal of the host cell ung gene. Use of host cells in the manufacture of pyrimidine deoxyribonucleotides e.g. thymidine is also disclosed.

Vectors, cells and processes for pyrimidine deoxyribonucleosides production

Enzyme treatment

A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Isolated protein from Eimeria useful as a cross species vaccine

Soil bacteria can be isolated which produce an enzyme capable of catalyzing the degradation of mannan-containing hemicellulose under conditions combining high pH and high temperature. Such bacteria can be cultured or used as sources of genetic information with which to engineer other microorganisms to produce the enzyme. Commercially useful quantities of native or recombinant hemicellulase can thus be produced by cultures consisting essentially of microorganisms capable of producing the enzyme.

Hemicellulase active at extremes of Ph and temperature and utilizing the

Hemicellulase active at PH and temperature extremes

Soil microorganisms are obtained that produce a hemicellulase which is particularly useful in increasing the available energy content of hemicellulosic foodstuffs. These microorganisms can be cultured per se or can be used as sources of genetic information with which to engineer other microorganisms to produce the enzyme. Thus, commercially useful quantities of native or recombinant hemicellulase can be produced with cultures consisting essentially of microorganisms that produce the enzyme. The hemicellulase can then be employed in a feed composition containing complex carbohydrates which the enzyme degrades, enhancing the nutritional value of the composition.

Hemicellulase supplement to improve the energy efficiency of

25 KD coccidial antigen of eimeria tenella

Growing community of inventors

Rockville, MD, United States of America

David M Anderson