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Lovejoy, David

Chen, Yani

David Lovejoy

Robert J Stein

Arij Al Chawaf

Marius Locke

Susan Rotzinger

Andrea D'Aquila

Dalia Barsyte

Andrew Slee

Yani Chen

R Bradley Chewpoy

Garo Armen

The present matter relates to compositions comprising Teneurin C-terminal Associated Peptide-1 (TCAP-1) and methods and uses of same for enhancing and/or restoring muscle function.

Compositions, methods and uses comprising teneurin C-terminal associated peptide -1 (TCAP-1) for enhancing muscle performance

Compositions comprising a Teneurin C-terminal Associated Peptide&#x2014;1 (TCAP-1) peptide are described with respect to methods and uses of same for preventing and/or treating post-traumatic stress disorder ('PTSD').

Compositions, methods and uses for treating post-traumatic stress disorder

This invention relates to a method of increasing energy available to skeletal muscle cells comprising administering to the cells an effective amount of Tenurin C-terminal Associated Peptide (TCAP). The invention provides the use of TCAP to enhance muscle performance or recovery after injury as well as to prevent and/or treat a number of conditions including insulin resistance, type II diabetes, hypoxia and glycogen storage diseases.

Method for modulating insulin-independent glucose transport using teneurin C-terminal associated peptide (TCAP)

This invention relates to a method of inhibiting neuronal cell death, including protecting neuronal cells from cell death and the effects of stress, such as high or low pH, comprising administering to the cells an effective amount of Teneurin C-terminal Associated Peptide (TCAP). The invention provides the use of TCAP to prevent and/or treat a number of brain conditions, such as hypoxia-ischemia and brain alkalosis or various brain or spinal cord injuries due to physical or physiological stresses. In one aspect the invention provides a use of TCAP to increase &#x3b2;-tubulin, &#x3b2;-actin levels in neuronal cells and/or to increase fasciculation among neuronal cells, in culture or in tissue. In another aspect, the invention provides a method of treating various pH induced neuronal conditions.

Method for regulating neurite growth

The invention provides a novel family of biologically active neuropeptides and the nucleic aid molecules coding for same. The peptides are derived for the C-terminus of the teneurin family peptides (Ten M1-4). These novel peptides, referred to as teneurin C-terminal associated peptides (TCAPs) are active in neuronal communication and are implicated in a number of neuropathologies. They are particularly useful in modulating stress responses and anxiety and in the treatment of cancer.

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Stouffville, Canada

David Lovejoy