May & Baker, Ltd.

David Lord Pain

Barbara Joyce Broughton

Stuart Malcolm Marshall

Kenneth Robert Wooldridge

Bryan John Large

8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

Azapurinones

The invention provides certain novel 8-azapurin-6-one derivatives substituted in the 2-position by a substituted phenyl group, preferably carrying an alkoxy in the 2-position, which possess valuable pharmacological properties especially in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.

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Upminster, United Kingdom

David Lord Pain